bw brown [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bwprovided by FlyBase
Official Full Name: brownprovided by FlyBase
Primary source: FLYBASE:FBgn0000241
Locus tag: Dmel_CG17632
See related: AllianceGenome:FB:FBgn0000241
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BW; CG17632; DmBrown; Dmel\CG17632; Pm; ptm; Su(w[co2]); Su(w[coJ])
Summary: Enables amine transmembrane transporter activity and guanine transmembrane transporter activity. Involved in several processes, including aminergic neurotransmitter loading into synaptic vesicle; guanine transport; and sensory perception of sound. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including Malpighian tubule primordium; adult head; apoptotic amnioserosa; embryonic/larval dorsal vessel; and embryonic/larval fat body. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 59E2-59E3; 2-103 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23527805..23538499, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19415328..19426022, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that when both spnA and lig4 were mutated and a circular donor was provided, the frequency of rosy mutations was still high and no HR products were recovered.
Title: Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila.
ry is required non-cell autonomously for the juvenile hormone effects.
Title: rosy Function is required for juvenile hormone effects in Drosophila melanogaster.
in the brown region, sequence elements in cis influence heterochromatic silencing in trans
Title: Sequence elements in cis influence heterochromatic silencing in trans.
Subject to trans-inactivation by artificially inserted mini-white gene.
Title: Differential gene silencing by trans-heterochromatin in Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c23537147-23529629 mobile_element_type = transposon:412{}6501

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables amine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanine transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye pigment precursor transport	TAS Traceable Author Statement more info	PubMed
involved_in guanine transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: brown

Names: CG17632-PA; CG17632-PD; brow; bw-PA; bw-PD; plum; pteridine-modifier; suppressor of white-coral J; suppressor of white-coral-2

NP_001286769.1

EC 7.2.2.-

complex mutation

NP_523824.1

EC 7.2.2.-

complex mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

23527805..23538499 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079100.3 → NP_523824.1 brown, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523824.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P12428, Q24264, Q7KVI1, Q7KVI2, Q8MRN9, Q9W1N7

UniProtKB/TrEMBL

A0A0B4LHB3

Related

FBpp0072026

Conserved Domains (3) summary

TIGR00955
Location:40 → 673

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

pfam01061
Location:404 → 604

ABC2_membrane; ABC-2 type transporter

cl21455
Location:31 → 316

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001299840.1 → NP_001286769.1 brown, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286769.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P12428, Q24264, Q7KVI1, Q7KVI2, Q8MRN9, Q9W1N7

UniProtKB/TrEMBL

A0A0B4LHB3

Conserved Domains (3) summary

TIGR00955
Location:40 → 673

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

pfam01061
Location:404 → 604

ABC2_membrane; ABC-2 type transporter

cl21455
Location:31 → 316

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases