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    wor worniu [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34906, updated on 17-Dec-2024

    Summary

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    Official Symbol
    worprovided by FlyBase
    Official Full Name
    worniuprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001983
    Locus tag
    Dmel_CG4158
    See related
    AllianceGenome:FB:FBgn0001983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS03023.1; br35; CG4158; Dmel\CG4158; l(2)35Da; l(2)br35; l35Da; Wor
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including nervous system development; positive regulation of transcription by RNA polymerase II; and regulation of neural precursor cell proliferation. Predicted to be active in nucleus. Is expressed in several structures, including central brain primordium; ganglia; larval optic anlage; neuroblasts; and unpaired neurons. Used to study central nervous system cancer. Human ortholog(s) of this gene implicated in piebaldism. Orthologous to human SNAI2 (snail family transcriptional repressor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wor in Genome Data Viewer
    Location:
    35D2-35D2; 2-51 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (15423297..15425580, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (15423297..15425580, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45374 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44861 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Worniu, a Snail family zinc-finger protein, is required for brain development in Drosophila. Ashraf SI, et al. Dev Dyn, 2004 Oct. PMID 15366015
    2. The Snail family member Worniu is continuously required in neuroblasts to prevent Elav-induced premature differentiation. Lai SL, et al. Dev Cell, 2012 Oct 16. PMID 23079601, Free PMC Article
    3. Actin-dependent membrane polarization reveals the mechanical nature of the neuroblast polarity cycle. LaFoya B, et al. Cell Rep, 2021 May 18. PMID 34010656, Free PMC Article
    4. Expression of Mammalian BM88/CEND1 in Drosophila Affects Nervous System Development by Interfering with Precursor Cell Formation. Tzortzopoulos A, et al. Neurosci Bull, 2019 Dec. PMID 31079319, Free PMC Article
    5. Identification of tightly regulated groups of genes during Drosophila melanogaster embryogenesis. Hooper SD, et al. Mol Syst Biol, 2007. PMID 17224916, Free PMC Article

    See all (128) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay.
      Title: Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay.
    2. The Worniu is continuously required in neuroblasts to maintain self-renewal by promoting cell-cycle progression and inhibiting premature differentiation.
      Title: The Snail family member Worniu is continuously required in neuroblasts to prevent Elav-induced premature differentiation.
    3. snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu.
      Title: The repressor function of snail is required for Drosophila gastrulation and is not replaceable by Escargot or Worniu.
    4. Results suggest that the loss of Worniu function within the neuroblasts ultimately causes the larval brainstem to fail to go through shortening during development.
      Title: Worniu, a Snail family zinc-finger protein, is required for brain development in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in asymmetric neuroblast division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neural precursor cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    worniu
    Names
    CG4158-PA
    D.m.Worniu
    lethal(2)35Da
    schnecke
    warniu
    wor-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      15423297..15425580 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057253.4 → NP_476601.1  worniu [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXL3, Q9U7P8, Q9VJP2
      Related
      FBpp0080299
      Conserved Domains (5) summary
      PHA00732
      Location:379 → 417
      PHA00732; hypothetical protein
      sd00017
      Location:408 → 428
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:434 → 456
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:421 → 444
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:405 → 482
      zf-C2H2_8; C2H2-type zinc ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXL3 Q8SXL3
    Q9U7P8 Q9U7P8
    Q9VJP2 Q9VJP2

    Gene LinkOut

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