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    l(3)mbn lethal (3) malignant blood neoplasm [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38701, updated on 27-Dec-2024

    Summary

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    Official Symbol
    l(3)mbnprovided by FlyBase
    Official Full Name
    lethal (3) malignant blood neoplasmprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002440
    Locus tag
    Dmel_CG12755
    See related
    AllianceGenome:FB:FBgn0002440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12755; Dmel\CG12755; l(3)malignant blood neoplasm1; l(3)mbn-1; l(3)mbn1; MBN
    Summary
    Predicted to be a structural constituent of chitin-based larval cuticle. Predicted to be involved in chitin-based cuticle development. Predicted to be located in plasma membrane. Predicted to be active in chitin-based extracellular matrix. Is expressed in several structures, including adult head; embryonic/larval fat body; embryonic/larval plasmatocyte; larval digestive system; and proplasmatocyte. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See l(3)mbn in Genome Data Viewer
    Location:
    65A6-65A6; 3-16 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6123934..6128807, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6117034..6121907, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene logjam Neighboring gene Ets at 65A Neighboring gene long non-coding RNA:CR46001 Neighboring gene antisense RNA:CR46005 Neighboring gene Larval cuticle protein Neighboring gene Cuticular protein 65Au

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A rapid rosetting method for separation of hemocyte sub-populations of Drosophila melanogaster. Vilmos P, et al. Dev Comp Immunol, 2004 May 17. PMID 15177109
    2. In vivo immunostaining of hemocyte compartments in Drosophila for live imaging. Csordás G, et al. PLoS One, 2014. PMID 24892745, Free PMC Article
    3. A Novel Method for Primary Blood Cell Culturing and Selection in Drosophila melanogaster. Kúthy-Sutus E, et al. Cells, 2022 Dec 21. PMID 36611818, Free PMC Article
    4. Immunoprofiling of Drosophila Hemocytes by Single-cell Mass Cytometry. Balog JÁ, et al. Genomics Proteomics Bioinformatics, 2021 Apr. PMID 33713850, Free PMC Article
    5. Cloning, structure, cellular localization, and possible function of the tumor suppressor gene lethal(3)malignant blood neoplasm-1 of Drosophila melanogaster. Konrad L, et al. Dev Biol, 1994 May. PMID 8174791

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural constituent of chitin-based larval cuticle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of chitin-based larval cuticle ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chitin-based extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chitin-based extracellular matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lethal (3) malignant blood neoplasm
    Names
    CG12755-PB
    CG12755-PD
    CG12755-PE
    l(3)mbn-PB
    l(3)mbn-PD
    l(3)mbn-PE
    lethal(3)malignant blood neoplasm-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6123934..6128807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316466.1 → NP_001303395.1  lethal (3) malignant blood neoplasm, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WGW8
      Conserved Domains (1) summary
      pfam00379
      Location:31 → 77
      Chitin_bind_4; Insect cuticle protein

    2. NM_001316467.1 → NP_001303396.1  lethal (3) malignant blood neoplasm, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WNZ2
      Conserved Domains (1) summary
      pfam00379
      Location:31 → 77
      Chitin_bind_4; Insect cuticle protein

    3. NM_168157.2 → NP_729143.2  lethal (3) malignant blood neoplasm, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729143.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52302, Q59E19, Q8MS87, Q9VRU6
      Related
      FBpp0076770
      Conserved Domains (1) summary
      pfam00379
      Location:31 → 77
      Chitin_bind_4; Insect cuticle protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WGW8 A0A0S0WGW8
    A0A0S0WNZ2 A0A0S0WNZ2
    P52302.2 P52302

    Gene LinkOut

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