5-HT1A 5-hydroxytryptamine (serotonin) receptor 1A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: 5-HT1Aprovided by FlyBase
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 1Aprovided by FlyBase
Primary source: FLYBASE:FBgn0004168
Locus tag: Dmel_CG16720
See related: AllianceGenome:FB:FBgn0004168
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 5-HT; 5-HT-1a; 5-HT-dro2A; 5-HT1a; 5-HT1ADro; 5-HT[1A]Dro; 5-HT[[1ADro]]; 5-HT[[1A]]; 5-HT[[1A]]DRO; 5HT; 5HT-1A; 5HT-dro2A; 5HT-drp[[2A]]; 5HT-R2A; 5HT1a; 5HT1A; 5htdro2a; 5HT[[1ADro]]; CG16720; d5-HT1A; Dm5-HT1A; Dm5-HT[[1A]]; Dm5HTdro2A; Dmel\CG16720; DRO2A; HT1A
Summary: Enables G protein-coupled serotonin receptor activity. Involved in several processes, including G protein-coupled serotonin receptor signaling pathway; anesthesia-resistant memory; and inter-male aggressive behavior. Predicted to be located in membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including adult brain; adult head; larval midline neurons; neurosecretory cell of brain; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; antisocial personality disorder; anxiety disorder (multiple); depressive disorder (multiple); and substance abuse (multiple). Orthologous to several human genes including HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 56B2-56B5; 2-88 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19067155..19121958)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14954660..15009463)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

5-HT1A regulates axon outgrowth in a subpopulation of Drosophila serotonergic neurons.
Title: 5-HT1A regulates axon outgrowth in a subpopulation of Drosophila serotonergic neurons.
Serotonergic modulation of visual neurons in Drosophila melanogaster.
Title: Serotonergic modulation of visual neurons in Drosophila melanogaster.
Activation of 5-HT1A and OAMB signaling in Insulin-producing cells generates differential effects on Dilp transcription, fly physiology, metabolism and social interactions.
Title: Drosophila insulin-producing cells are differentially modulated by serotonin and octopamine receptors and affect social behavior.
serotonin acts on brain IPCs via the 5-HT(1A) receptor, thereby affecting their activity and probably insulin signaling
Title: Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT1A receptor.
study describes the influence of different 5-HT receptor subtypes on aggressive behaviors; activation of 5-HT(1A)-like receptors with 8-OH-DPAT increases overall aggression; 5-HT(1A)-like receptor manipulation primarily affects wing threats and fencing
Title: Serotonin 5-HT(2) and 5-HT(1A)-like receptors differentially modulate aggressive behaviors in Drosophila melanogaster.
Decrease in 5-HT(1A) receptor binding partly reflects hippocampal neuronal loss in temporal lobe epilepsy.
Title: Statistical parametric mapping of 5-HT1A receptor binding in temporal lobe epilepsy with hippocampal ictal onset on intracranial EEG.
The Drosophila serotonin receptor 1A has a role in promoting baseline sleep.
Title: A sleep-promoting role for the Drosophila serotonin receptor 1A.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled amine receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled serotonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled serotonin receptor activity	TAS Traceable Author Statement more info	PubMed
enables Gi/o-coupled serotonin receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in anesthesia-resistant memory	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in inter-male aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating serotonin receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: 5-hydroxytryptamine (serotonin) receptor 1A

Names: 5-HT1A-PB; 5-HT1A-PC; CG16720-PB; CG16720-PC; serotonin receptor 1A; serotonin receptor 2A; serotonin-receptor-2A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

19067155..19121958

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001369983.1 → NP_001356890.1 5-hydroxytryptamine (serotonin) receptor 1A, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P28285, Q0E921, Q4QQC9, Q5MTE9, Q5MTF1, Q5MTF2, Q5MTF3, Q5MTF8, Q5MTF9, Q5MTG0, Q5MTG1, Q5MTG2, Q5MTG3, Q5MTG4, Q5MTG6, Q5MTG9, Q5MTH1, Q5MTH2, Q5MTH5, Q5MTH6, Q5MTH7, Q5MTH9, Q5MTI0, Q5MTI1

Conserved Domains (3) summary

cd15331
Location:227 → 413

7tmA_5-HT1A_invertebrates; serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors

cd14964
Location:747 → 772

7tm_GPCRs; TM helix 6 [structural motif]

cl28897
Location:743 → 816

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_166322.2 → NP_725849.1 5-hydroxytryptamine (serotonin) receptor 1A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725849.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P28285, Q0E921, Q4QQC9, Q5MTE9, Q5MTF1, Q5MTF2, Q5MTF3, Q5MTF8, Q5MTF9, Q5MTG0, Q5MTG1, Q5MTG2, Q5MTG3, Q5MTG4, Q5MTG6, Q5MTG9, Q5MTH1, Q5MTH2, Q5MTH5, Q5MTH6, Q5MTH7, Q5MTH9, Q5MTI0, Q5MTI1

Related

FBpp0085761

Conserved Domains (1) summary

pfam00001
Location:243 → 413

7tm_1; 7 transmembrane receptor (rhodopsin family)