Mdr50 Multi drug resistance 50 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mdr50provided by FlyBase
Official Full Name: Multi drug resistance 50provided by FlyBase
Primary source: FLYBASE:FBgn0010241
Locus tag: Dmel_CG8523
See related: AllianceGenome:FB:FBgn0010241
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8523; Dm2; Dm3; Dmel\CG8523; DmMdr50; mdr50; MDR50
Summary: Predicted to enable ABC-type xenobiotic transporter activity and efflux transmembrane transporter activity. Involved in renal tubular secretion and response to insecticide. Predicted to be located in plasma membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex. Predicted to be active in membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including cholestasis (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 50E6-50E6; 2-69 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14246966..14252597)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10134471..10140102)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

influences tolerance to insecticide exposure
Title: Describing the role of Drosophila melanogaster ABC transporters in insecticide biology using CRISPR-Cas9 knockouts.

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables efflux transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in renal tubular secretion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insecticide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of ATP-binding cassette (ABC) transporter complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: multi drug resistance 50

Names: CG8523-PA; Mdr50-PA; multi-drug resistance 50

NP_523740.3

EC 7.2.2.-

EC 7.6.2.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

14246966..14252597

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079016.3 → NP_523740.3 multi drug resistance 50 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523740.3

Status: REVIEWED

UniProtKB/TrEMBL

Q24393, Q5BI62, Q9TX79

Conserved Domains (3) summary

cd03249
Location:431 → 668

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:69 → 1308

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:92 → 382

ABC_membrane; ABC transporter transmembrane region