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    CG12099 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38181, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12099provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035232
    Locus tag
    Dmel_CG12099
    See related
    AllianceGenome:FB:FBgn0035232
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12099
    Summary
    Predicted to enable transcription cis-regulatory region binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and protein autoubiquitination. Is expressed in organism. Orthologous to human RNF10 (ring finger protein 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12099 in Genome Data Viewer
    Location:
    62A5-62A5; 3-0.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1555363..1558484, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1555363..1558484, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Phosphocholine cytidylyltransferase 1 Neighboring gene antisense RNA:CR45813 Neighboring gene Phosphocholine cytidylyltransferase 2 Neighboring gene Peroxin 10 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Transmembrane endosomal protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OTUD6 deubiquitination of RPS7/eS7 on the free 40 S ribosome regulates global protein translation and stress. Villa S, et al. Nat Commun, 2024 Aug 11. PMID 39127721, Free PMC Article
    2. HSP90 as a global genetic modifier for male genital morphology in Drosophila melanogaster. Takahashi KH, et al. Evolution, 2018 Nov. PMID 30221481
    3. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article
    4. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. Palu RA, et al. PLoS Genet, 2016 Apr. PMID 27058248, Free PMC Article
    5. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12099-PA
    CG12099-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1555363..1558484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167895.2 → NP_728629.1  uncharacterized protein Dmel_CG12099, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728629.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0D8
      Related
      FBpp0072709
      Conserved Domains (1) summary
      pfam13923
      Location:212 → 253
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    2. NM_139366.3 → NP_647623.1  uncharacterized protein Dmel_CG12099, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647623.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W0D8
      Related
      FBpp0072708
      Conserved Domains (1) summary
      pfam13923
      Location:212 → 253
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W0D8 Q9W0D8

    Gene LinkOut

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