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    Etf-QO Electron transfer flavoprotein-ubiquinone oxidoreductase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36031, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Etf-QOprovided by FlyBase
    Official Full Name
    Electron transfer flavoprotein-ubiquinone oxidoreductaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0286783
    Locus tag
    Dmel_CG12140
    See related
    AllianceGenome:FB:FBgn0286783
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG 12140; CG12140; Dmel\CG12140; ETF:QO; ETFD; ETFDH; EtfQ0; I; l(2)46Ca
    Summary
    Enables electron-transferring-flavoprotein dehydrogenase activity. Involved in fatty acid beta-oxidation. Located in mitochondrion. Is expressed in adult head and adult heart. Used to study multiple acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Etf-QO in Genome Data Viewer
    Location:
    46C4-46C4; 2-61 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9910893..9913488)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5798398..5800993)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene FMRFamide Neighboring gene Myocyte enhancer factor 2 Neighboring gene Pdrg1 prefoldin-like subunit Neighboring gene Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations at the flavin binding site of ETF:QO yield a MADD-like severe phenotype in Drosophila. Alves E, et al. Biochim Biophys Acta, 2012 Aug. PMID 22580358
    2. The critical role of Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase during dark-induced starvation. Ishizaki K, et al. Plant Cell, 2005 Sep. PMID 16055629, Free PMC Article
    3. orsai, the Drosophila homolog of human ETFRF1, links lipid catabolism to growth control. Fernandez-Acosta M, et al. BMC Biol, 2022 Oct 21. PMID 36266680, Free PMC Article
    4. The TreadWheel: A Novel Apparatus to Measure Genetic Variation in Response to Gently Induced Exercise for Drosophila. Mendez S, et al. PLoS One, 2016. PMID 27736996, Free PMC Article
    5. A genetic and molecular analysis of the 46C chromosomal region surrounding the FMRFamide neuropeptide gene in Drosophila melanogaster. O'Brien MA, et al. Genetics, 1994 May. PMID 8056304, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables electron-transferring-flavoprotein dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron-transferring-flavoprotein dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables electron-transferring-flavoprotein dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    electron transfer flavoprotein-ubiquinone oxidoreductase
    Names
    CG12140-PA
    CG12140-PB
    Etf-QO-PA
    Etf-QO-PB
    electron transfer flavoprotein:ubiquinone oxidoreductase
    group I
    lethal (2) 46Ca
    NP_001246231.1
    NP_610536.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9910893..9913488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136692.1 → NP_610536.1  electron transfer flavoprotein-ubiquinone oxidoreductase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JWF1
      Related
      FBpp0087472, FBtr0088384
      Conserved Domains (3) summary
      COG0644
      Location:56 → 516
      FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
      pfam05187
      Location:499 → 602
      ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S
      cl21454
      Location:44 → 206
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001259302.1 → NP_001246231.1  electron transfer flavoprotein-ubiquinone oxidoreductase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246231.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JWF1
      Conserved Domains (3) summary
      COG0644
      Location:56 → 516
      FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
      pfam05187
      Location:499 → 602
      ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S
      cl21454
      Location:44 → 206
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JWF1 Q7JWF1

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