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    Golgin245 Golgin-245 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Golgin245provided by FlyBase
    Official Full Name
    Golgin-245provided by FlyBase
    Primary source
    FLYBASE:FBgn0034854
    Locus tag
    Dmel_CG3493
    See related
    AllianceGenome:FB:FBgn0034854
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3493; dGolgin-245; dGolgin245; Dmel\CG3493; g245; golgin245
    Summary
    Enables small GTPase binding activity. Predicted to be involved in Golgi vesicle transport. Located in Golgi trans cisterna. Is active in trans-Golgi network membrane. Is expressed in adult head and spermatozoon. Orthologous to human GOLGA4 (golgin A4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Golgin245 in Genome Data Viewer
    Location:
    59D9-59D9; 2-102 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23371360..23377045, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19258883..19264568, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44168 Neighboring gene uncharacterized protein Neighboring gene Methenyltetrahydrofolate synthetase Neighboring gene virilizer Neighboring gene Interacts with the C terminus of ELL 1 Neighboring gene uncharacterized protein Neighboring gene yellow-d Neighboring gene yellow-d2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo characterization of Drosophila golgins reveals redundancy and plasticity of vesicle capture at the Golgi apparatus. Park SY, et al. Curr Biol, 2022 Nov 7. PMID 36103876, Free PMC Article
    2. An antibody toolkit for the study of membrane traffic in Drosophila melanogaster. Riedel F, et al. Biol Open, 2016 Jul 15. PMID 27256406, Free PMC Article
    3. HEATR5B associates with dynein-dynactin and promotes motility of AP1-bound endosomal membranes. Madan V, et al. EMBO J, 2023 Dec 1. PMID 37872872, Free PMC Article
    4. An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1. Herlo R, et al. Cell Rep, 2018 May 15. PMID 29768204
    5. bicoid RNA localization requires the trans-Golgi network. Cai X, et al. Hereditas, 2019. PMID 31528161, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi vesicle transport IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Golgin-245
    Names
    CG3493-PA
    Golgin-245 ortholog
    Golgin245-PA
    golgin 245

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23371360..23377045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137943.3 → NP_611787.2  Golgin-245 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611787.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T8Q5, Q9W1R3
      Related
      FBpp0071945
      Conserved Domains (4) summary
      smart00755
      Location:1433 → 1477
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:286 → 1089
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl00459
      Location:1244 → 1333
      MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
      cl15838
      Location:306 → 421
      Phage_GPO; Phage capsid scaffolding protein (GPO) serine peptidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T8Q5 Q8T8Q5
    Q9W1R3 Q9W1R3

    Gene LinkOut

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