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    CG8219 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8219provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035693
    Locus tag
    Dmel_CG8219
    See related
    AllianceGenome:FB:FBgn0035693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    148274_at; Dmel\CG8219; EP(3)3072
    Summary
    Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human TNPO1 (transportin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8219 in Genome Data Viewer
    Location:
    65A8-65A8; 3-16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6200473..6203776)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6193573..6196876)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Splicing factor 3b subunit 6 Neighboring gene Transportin Neighboring gene Laminin A Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila. Jäckel S, et al. Neurobiol Dis, 2015 Feb. PMID 25447237
    2. Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/Kapβ2 in Hedgehog signaling. Shi Q, et al. J Cell Sci, 2014 Mar 1. PMID 24413177, Free PMC Article
    3. Nuclear transport genes recurrently duplicate by means of RNA intermediates in Drosophila but not in other insects. Mirsalehi A, et al. BMC Genomics, 2021 Dec 5. PMID 34863092, Free PMC Article
    4. The Ketel gene encodes a Drosophila homologue of importin-beta. Lippai M, et al. Genetics, 2000 Dec. PMID 11102382, Free PMC Article
    5. Frequent recent origination of brain genes shaped the evolution of foraging behavior in Drosophila. Chen S, et al. Cell Rep, 2012 Feb 23. PMID 22832161, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear localization sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8219-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6200473..6203776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139781.1 → NP_648038.1  uncharacterized protein Dmel_CG8219 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648038.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSM3, Q9VRV9
      Related
      FBpp0076711, FBtr0077003
      Conserved Domains (5) summary
      cd00020
      Location:104 → 214
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam03810
      Location:11 → 76
      IBN_N; Importin-beta N-terminal domain
      pfam13513
      Location:373 → 424
      HEAT_EZ; HEAT-like repeat
      pfam13646
      Location:361 → 465
      HEAT_2; HEAT repeats
      sd00044
      Location:104 → 132
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSM3 Q8MSM3
    Q9VRV9 Q9VRV9

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