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    qjt quijote [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39952, updated on 17-Dec-2024

    Summary

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    Official Symbol
    qjtprovided by FlyBase
    Official Full Name
    quijoteprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036730
    Locus tag
    Dmel_CG13732
    See related
    AllianceGenome:FB:FBgn0036730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13732; Dmel\CG13732; Nse2; Qjt; Quijote
    Summary
    Predicted to enable SUMO ligase activity. Involved in double-strand break repair via homologous recombination. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See qjt in Genome Data Viewer
    Location:
    74C4-74C4; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17479096..17480141)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17472196..17473241)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Organic anion transporting polypeptide 74D Neighboring gene elevated during infection Neighboring gene U4-U6 small nuclear riboprotein factor 60K

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA double-strand break movement in heterochromatin depends on the histone acetyltransferase dGcn5. Kendek A, et al. Nucleic Acids Res, 2024 Oct 28. PMID 39258543, Free PMC Article
    2. Cervantes and Quijote protect heterochromatin from aberrant recombination and lead the way to the nuclear periphery. Ryu T, et al. Nucleus, 2016 Sep 2. PMID 27673416, Free PMC Article
    3. Fast protein evolution and germ line expression of a Drosophila parental gene and its young retroposed paralog. Betrán E, et al. Mol Biol Evol, 2006 Nov. PMID 16916943
    4. The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster. Li X, et al. PLoS One, 2013. PMID 23555814, Free PMC Article
    5. Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Chiolo I, et al. Cell, 2011 Mar 4. PMID 21353298, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Smc5-Smc6 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    quijote
    Names
    CG13732-PA
    CG13732-PB
    qjt-PA
    qjt-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17479096..17480141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140730.4 → NP_648987.1  quijote, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648987.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5IF66, Q9VVH7
      Related
      FBpp0074985
      Conserved Domains (1) summary
      cl17238
      Location:135 → 194
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_001275059.1 → NP_001261988.1  quijote, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5IF66, Q9VVH7
      Conserved Domains (1) summary
      cl17238
      Location:135 → 194
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q008Y9 Q008Y9
    Q008Z0 Q008Z0
    Q8I0B8 Q8I0B8
    Q8I8H8 Q8I8H8
    Q8I8H9 Q8I8H9
    Q8I8I0 Q8I8I0
    Q8I8I1 Q8I8I1
    Q9VVH7 Q9VVH7

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