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    Qsox3 Quiescin sulfhydryl oxidase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Qsox3provided by FlyBase
    Official Full Name
    Quiescin sulfhydryl oxidase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0038918
    Locus tag
    Dmel_CG6690
    See related
    AllianceGenome:FB:FBgn0038918
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6690; Dmel\CG6690
    Summary
    Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1) and QSOX2 (quiescin sulfhydryl oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Qsox3 in Genome Data Viewer
    Location:
    93F14-93F14; 3-73 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21911816..21913591)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17737538..17739313)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene dead end Neighboring gene Quiescin sulfhydryl oxidase 2 Neighboring gene Ecdysone-induced protein 93F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. BMP signaling inhibition in Drosophila secondary cells remodels the seminal proteome and self and rival ejaculate functions. Hopkins BR, et al. Proc Natl Acad Sci U S A, 2019 Dec 3. PMID 31740617, Free PMC Article
    2. Nonadaptive molecular evolution of seminal fluid proteins in Drosophila. Patlar B, et al. Evolution, 2021 Aug. PMID 34184267, Free PMC Article
    3. Evolutionary EST analysis identifies rapidly evolving male reproductive proteins in Drosophila. Swanson WJ, et al. Proc Natl Acad Sci U S A, 2001 Jun 19. PMID 11404480, Free PMC Article
    4. Genome-wide analysis of nuclear mRNA export pathways in Drosophila. Herold A, et al. EMBO J, 2003 May 15. PMID 12743041, Free PMC Article
    5. Cross-species comparison of Drosophila male accessory gland protein genes. Mueller JL, et al. Genetics, 2005 Sep. PMID 15944345, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin-dependent sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    quiescin sulfhydryl oxidase 3
    Names
    CG6690-PA
    Qsox3-PA
    NP_650997.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21911816..21913591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142740.2 → NP_650997.1  quiescin sulfhydryl oxidase 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650997.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V583, Q9VD62
      Related
      FBpp0083547
      Conserved Domains (2) summary
      cd02992
      Location:40 → 153
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:413 → 503
      Evr1_Alr; Erv1 / Alr family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD62 Q9VD62

    Gene LinkOut

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