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    Nhe2 Na[+]/H[+] hydrogen exchanger 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35376, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Nhe2provided by FlyBase
    Official Full Name
    Na[+]/H[+] hydrogen exchanger 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0040297
    Locus tag
    Dmel_CG9256
    See related
    AllianceGenome:FB:FBgn0040297
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9255; CG9256; Dmel\CG9256; DmNHE2; dNhe2; Dnhe2; DNhe2; nhe2; NHE2
    Summary
    Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Involved in compound eye morphogenesis; intracellular pH elevation; and renal system process. Located in apical plasma membrane. Is expressed in several structures, including embryonic/larval hemocyte; embryonic/larval midgut primordium; gonad; head epidermis primordium; and somatic trunk mesoderm derivative. Used to study nephrolithiasis. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19; congenital secretory sodium diarrhea 8; congestive heart failure; and end stage renal disease. Orthologous to several human genes including SLC9A3 (solute carrier family 9 member A3) and SLC9A5 (solute carrier family 9 member A5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Nhe2 in Genome Data Viewer
    Location:
    39A2-39A3; 2-54 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21104568..21134255)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21104568..21134255)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lethal (2) 05287 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43809 Neighboring gene long non-coding RNA:CR44056 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dynamin associated protein 160 Neighboring gene ncRNA Neighboring gene porthos

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila anion exchanger 2 is required for proper ovary development and oogenesis. Benitez M, et al. Dev Biol, 2019 Aug 15. PMID 31071312, Free PMC Article
    2. Increased H⁺ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression. Grillo-Hill BK, et al. Elife, 2015 Mar 20. PMID 25793441, Free PMC Article
    3. Drosophila Nhe2 overexpression induces autophagic cell death. Peralta J, et al. Mol Biol Cell, 2024 Jul 1. PMID 38696256, Free PMC Article
    4. β-Catenin is a pH sensor with decreased stability at higher intracellular pH. White KA, et al. J Cell Biol, 2018 Nov 5. PMID 30315137, Free PMC Article
    5. Evolutionary origins of eukaryotic sodium/proton exchangers. Brett CL, et al. Am J Physiol Cell Physiol, 2005 Feb. PMID 15643048

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Nhe2 overexpression induces autophagic cell death.
      Title: Drosophila Nhe2 overexpression induces autophagic cell death.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 21112155-21112301 mobile_element_type = transposon:INE-1{}5356

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables potassium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:proton antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular monoatomic ion homeostasis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in intracellular pH elevation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cellular pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of pH IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in renal system process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sodium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Na[+]/H[+] hydrogen exchanger 2
    Names
    CG9256-PA
    CG9256-PB
    CG9256-PC
    CG9256-PD
    CG9256-PE
    CG9256-PF
    CG9256-PG
    CG9256-PH
    CG9256-PI
    CG9256-PJ
    CG9256-PK
    CG9256-PL
    Nhe2-PA
    Nhe2-PB
    Nhe2-PC
    Nhe2-PD
    Nhe2-PE
    Nhe2-PF
    Nhe2-PG
    Nhe2-PH
    Nhe2-PI
    Nhe2-PJ
    Nhe2-PK
    Nhe2-PL
    drosophila sodium-proton exchanger 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21104568..21134255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273733.1 → NP_001260662.1  Na[+]/H[+] hydrogen exchanger 2, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGE2, Q9NGZ4
      Conserved Domains (2) summary
      TIGR00840
      Location:189 → 704
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:199 → 602
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    2. NM_001144377.3 → NP_001137849.1  Na[+]/H[+] hydrogen exchanger 2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137849.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZY1, Q9NGZ4
      Conserved Domains (2) summary
      TIGR00840
      Location:189 → 704
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:199 → 602
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    3. NM_165355.4 → NP_724311.1  Na[+]/H[+] hydrogen exchanger 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724311.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGZ4, Q9VIF9
      Related
      FBpp0080995
      Conserved Domains (2) summary
      TIGR00840
      Location:189 → 704
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:199 → 602
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    4. NM_001273732.1 → NP_001260661.1  Na[+]/H[+] hydrogen exchanger 2, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260661.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDJ7, Q8MQP4
      Conserved Domains (2) summary
      TIGR00840
      Location:189 → 704
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:199 → 602
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    5. NM_001259188.2 → NP_001246117.1  Na[+]/H[+] hydrogen exchanger 2, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NFD1, Q8MQP4
      Conserved Domains (2) summary
      TIGR00840
      Location:189 → 704
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:199 → 602
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    6. NM_001144379.3 → NP_001137851.1  Na[+]/H[+] hydrogen exchanger 2, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137851.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZY2, Q9NGZ4
      Conserved Domains (2) summary
      TIGR00840
      Location:189 → 704
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:199 → 602
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    7. NM_136244.5 → NP_610088.2  Na[+]/H[+] hydrogen exchanger 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610088.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGZ4, Q9VIF9
      Related
      FBpp0080996
      Conserved Domains (2) summary
      TIGR00840
      Location:189 → 704
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:199 → 602
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    8. NM_001144375.3 → NP_001137847.1  Na[+]/H[+] hydrogen exchanger 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137847.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZY3, Q9NGZ4
      Conserved Domains (2) summary
      TIGR00840
      Location:189 → 704
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:199 → 602
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    9. NM_001259187.2 → NP_001246116.1  Na[+]/H[+] hydrogen exchanger 2, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDU7, Q8MQP4
      Conserved Domains (2) summary
      TIGR00840
      Location:189 → 704
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:199 → 602
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    10. NM_001144376.2 → NP_001137848.1  Na[+]/H[+] hydrogen exchanger 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137848.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZY5, Q8WPH4
      Conserved Domains (1) summary
      pfam00999
      Location:246 → 602
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    11. NM_001144378.2 → NP_001137850.1  Na[+]/H[+] hydrogen exchanger 2, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137850.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZY4, Q8WPH4
      Conserved Domains (1) summary
      pfam00999
      Location:246 → 602
      Na_H_Exchanger; Sodium/hydrogen exchanger family

    12. NM_001273731.1 → NP_001260660.1  Na[+]/H[+] hydrogen exchanger 2, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260660.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDW6, Q9NGZ4
      Conserved Domains (2) summary
      TIGR00840
      Location:189 → 704
      b_cpa1; sodium/hydrogen exchanger 3
      pfam00999
      Location:199 → 602
      Na_H_Exchanger; Sodium/hydrogen exchanger family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZY1 B7YZY1
    B7YZY2 B7YZY2
    B7YZY3 B7YZY3
    B7YZY4 B7YZY4
    B7YZY5 B7YZY5
    M9NDU7 M9NDU7
    M9NFD1 M9NFD1
    M9PDJ7 M9PDJ7
    M9PDW6 M9PDW6
    M9PGE2 M9PGE2
    Q8MQP4 Q8MQP4
    Q8WPH4 Q8WPH4
    Q9NGU8 Q9NGU8
    Q9NGZ4 Q9NGZ4
    Q9VIF9 Q9VIF9

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