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    Nuak Nuak family kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nuakprovided by FlyBase
    Official Full Name
    Nuak family kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262617
    Locus tag
    Dmel_CG43143
    See related
    AllianceGenome:FB:FBgn0262617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11870; CG11871; CG11872; CG43143; Dmel\CG43143; EMK/KIAA0537; NUAK; Nuak1; Omphk1
    Old locus tag
    Dmel_CG11870; Dmel_CG11872
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be located in cytoplasm and nucleus. Is expressed in adult head. Human ortholog(s) of this gene implicated in anencephaly and uterine fibroid. Orthologous to human NUAK1 (NUAK family kinase 1) and NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nuak in Genome Data Viewer
    Location:
    86A3-86A7; 3-49 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10264306..10308467)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6090028..6134189)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Sirtuin 6 Neighboring gene pontin Neighboring gene transfer RNA:Serine-GCT 2-1 Neighboring gene uncharacterized protein Neighboring gene BIR repeat containing ubiquitin-conjugating enzyme Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene expression profiling of NUAK kinase overexpression in Drosophila larval muscle development. Brooks D, et al. Data Brief, 2022 Aug. PMID 35924094, Free PMC Article
    2. Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Lasagna-Reeves CA, et al. Neuron, 2016 Oct 19. PMID 27720485, Free PMC Article
    3. A new serine/threonine protein kinase, Omphk1, essential to ventral body wall formation. Hirano M, et al. Dev Dyn, 2006 Aug. PMID 16715502
    4. Identification of CryAB as a target of NUAK kinase activity in Drosophila muscle tissue. Zhao Z, et al. Genetics, 2023 Nov 1. PMID 37713608, Free PMC Article
    5. Independent pathways control muscle tissue size and sarcomere remodeling. Brooks D, et al. Dev Biol, 2022 Oct. PMID 35760368, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of CryAB as a target of NUAK kinase activity in Drosophila muscle tissue.
      Title: Identification of CryAB as a target of NUAK kinase activity in Drosophila muscle tissue.
    2. NUAK interacts with Starvin and controls autophagic protein turnover.
      Title: Drosophila NUAK functions with Starvin/BAG3 in autophagic protein turnover.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuak family kinase
    Names
    CG43143-PA
    CG43143-PB
    CG43143-PC
    CG43143-PD
    CG43143-PE
    CG43143-PF
    CG43143-PG
    CG43143-PH
    CG43143-PI
    CG43143-PJ
    CG43143-PK
    CG43143-PL
    CG43143-PM
    CG43143-PN
    CG43143-PO
    CG43143-PP
    CG43143-PQ
    Nuak-PA
    Nuak-PB
    Nuak-PC
    Nuak-PD
    Nuak-PE
    Nuak-PF
    Nuak-PG
    Nuak-PH
    Nuak-PI
    Nuak-PJ
    Nuak-PK
    Nuak-PL
    Nuak-PM
    Nuak-PN
    Nuak-PO
    Nuak-PP
    Nuak-PQ
    Nuak1 ortholog
    nuak family kinase 1
    NP_001247019.1
    • unusual splice
    NP_001247020.1
    • unusual splice
    NP_001262457.1
    • unusual splice
    NP_001262458.1
    • unusual splice
    NP_001369002.1
    NP_001369003.1
    • unusual splice
    NP_001369004.1
    • unusual splice
    NP_001369005.1
    • unusual splice
    NP_001369006.1
    • unusual splice
    NP_001369007.1
    • unusual splice
    NP_001369008.1
    • unusual splice
    NP_001369009.1
    • unusual splice
    NP_649991.2
    • unusual splice
    NP_649993.2
    • unusual splice
    NP_731469.2
    • unusual splice
    NP_996191.1
    • unusual splice
    NP_996192.1
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10264306..10308467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001382101.1 → NP_001369005.1  nuak family kinase, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EG35
      Conserved Domains (1) summary
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    2. NM_001275529.1 → NP_001262458.1  nuak family kinase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262458.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFP5
      Conserved Domains (2) summary
      smart00220
      Location:70 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    3. NM_001382098.1 → NP_001369002.1  nuak family kinase, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EEU5
      Conserved Domains (1) summary
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    4. NM_001382102.1 → NP_001369006.1  nuak family kinase, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH03
      Conserved Domains (1) summary
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    5. NM_001382103.1 → NP_001369007.1  nuak family kinase, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGR1
      Conserved Domains (1) summary
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    6. NM_001260090.1 → NP_001247019.1  nuak family kinase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247019.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K707
      Conserved Domains (1) summary
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    7. NM_001382099.1 → NP_001369003.1  nuak family kinase, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EDN5, Q7YU19
      Conserved Domains (1) summary
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    8. NM_206469.3 → NP_996191.1  nuak family kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996191.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KSS0, Q7YU19
      Conserved Domains (1) summary
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    9. NM_169337.2 → NP_731469.2  nuak family kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731469.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI87, Q7YU19
      Related
      FBpp0293893, FBtr0305354
      Conserved Domains (2) summary
      smart00220
      Location:70 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    10. NM_001382100.1 → NP_001369004.1  nuak family kinase, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH03
      Conserved Domains (1) summary
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    11. NM_001275528.1 → NP_001262457.1  nuak family kinase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262457.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGR1
      Conserved Domains (1) summary
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    12. NM_001382104.1 → NP_001369008.1  nuak family kinase, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K707
      Conserved Domains (1) summary
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    13. NM_001382105.1 → NP_001369009.1  nuak family kinase, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EDN5, Q7YU19
      Conserved Domains (1) summary
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    14. NM_206470.1 → NP_996192.1  nuak family kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996192.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI87, Q7YU19
      Conserved Domains (2) summary
      smart00220
      Location:70 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    15. NM_141736.3 → NP_649993.2  nuak family kinase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649993.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VH03
      Conserved Domains (1) summary
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    16. NM_001260091.1 → NP_001247020.1  nuak family kinase, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247020.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6D8, Q7YU19
      Conserved Domains (2) summary
      smart00220
      Location:70 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK

    17. NM_141734.2 → NP_649991.2  nuak family kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649991.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI87, Q7YU19
      Related
      FBpp0293891, FBtr0305352
      Conserved Domains (2) summary
      smart00220
      Location:70 → 321
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14073
      Location:68 → 321
      STKc_NUAK; Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6D8 A0A0B4K6D8
    A0A0B4K707 A0A0B4K707
    A0A0B4KFP5 A0A0B4KFP5
    A0A0B4KGR1 A0A0B4KGR1
    A0A6H2EDN5 A0A6H2EDN5
    A0A6H2EEU5 A0A6H2EEU5
    A0A6H2EG35 A0A6H2EG35
    Q0KI87 Q0KI87
    Q7KSS0 Q7KSS0
    Q7YU19 Q7YU19
    Q9VH03 Q9VH03

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