Su(var)2-HP2 Su(var)2-HP2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Su(var)2-HP2provided by FlyBase
Official Full Name: Su(var)2-HP2provided by FlyBase
Primary source: FLYBASE:FBgn0026427
Locus tag: Dmel_CG12864
See related: AllianceGenome:FB:FBgn0026427
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12864; Dmel\CG12864; Hp2; HP2; SU(VAR)2-HP2
Summary: Predicted to enable DNA binding activity. Involved in heterochromatin formation and mitotic chromosome condensation. Located in condensed chromosome and heterochromatin. Is expressed in embryonic brain; larval ventral nerve cord; organism; and spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14607154..14618118, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10494659..10505623, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

a role in heterochromatin spreading and gene silencing
Title: Heterochromatin protein 2 (HP2), a partner of HP1 in Drosophila heterochromatin.
The large isoform of HP2 plays a critical role in gene silencing and chromosome structure.
Title: The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in polytene chromosome	TAS Traceable Author Statement more info	PubMed

Names: CG12864-PA; CG12864-PB; Su(var)2-HP2-PA; Su(var)2-HP2-PB; heterochromatic protein 2; heterochromatin protein 2

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