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    Qsox2 Quiescin sulfhydryl oxidase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42583, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Qsox2provided by FlyBase
    Official Full Name
    Quiescin sulfhydryl oxidase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0038919
    Locus tag
    Dmel_CG17843
    See related
    AllianceGenome:FB:FBgn0038919
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.66; CG17843; Dmel\CG17843; DmQSOX2; Erv1
    Summary
    Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head and male accessory gland. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1) and QSOX2 (quiescin sulfhydryl oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Qsox2 in Genome Data Viewer
    Location:
    93F14-93F14; 3-73 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21913747..21915546)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17739469..17741268)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Quiescin sulfhydryl oxidase 3 Neighboring gene Ecdysone-induced protein 93F Neighboring gene Testicular haploid expressed gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. Thorpe C, et al. Arch Biochem Biophys, 2002 Sep 1. PMID 12176051
    2. Identification of potential pathways and biomarkers linked to progression in ALS. Huber RG, et al. Ann Clin Transl Neurol, 2023 Feb. PMID 36533811, Free PMC Article
    3. Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation. Liu J, et al. Hereditas, 2022 Oct 21. PMID 36271387, Free PMC Article
    4. Comparative structural modeling and inference of conserved protein classes in Drosophila seminal fluid. Mueller JL, et al. Proc Natl Acad Sci U S A, 2004 Sep 14. PMID 15345744, Free PMC Article
    5. Genome-wide mapping of in vivo targets of the Drosophila transcription factor Kruppel. Matyash A, et al. J Biol Chem, 2004 Jul 16. PMID 15131112

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin-dependent sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    quiescin sulfhydryl oxidase 2
    Names
    CG17843-PA
    Qsox2-PA
    NP_650998.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21913747..21915546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142741.4 → NP_650998.1  quiescin sulfhydryl oxidase 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650998.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VD61
      Related
      FBpp0083548
      Conserved Domains (2) summary
      cd02992
      Location:40 → 152
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:413 → 504
      Evr1_Alr; Erv1 / Alr family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD61 Q9VD61

    Gene LinkOut

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