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    RPA2 Replication protein A2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35364, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RPA2provided by FlyBase
    Official Full Name
    Replication protein A2provided by FlyBase
    Primary source
    FLYBASE:FBgn0288834
    Locus tag
    Dmel_CG9273
    See related
    AllianceGenome:FB:FBgn0288834
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    153194_at; CG9273; D-SSB; Dmel\CG9273; DmRP-A; DmRPA; dRP-A; DRP-A; dRPA2; RP-A; RPA; RPA 30 kDa; RpA-30; RpA2; RPA30; Ssb-30
    Summary
    Predicted to enable single-stranded DNA binding activity and telomeric DNA binding activity. Predicted to be involved in DNA replication; double-strand break repair via homologous recombination; and nucleotide-excision repair. Predicted to be located in nucleus. Predicted to be part of DNA replication factor A complex. Predicted to be active in chromosome, telomeric region and site of double-strand break. Is expressed in several structures, including antennal primordium; embryonic/larval midgut primordium; ganglia; gut section; and head epidermis primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RPA2 in Genome Data Viewer
    Location:
    38F6-38F6; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20924975..20926147, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20924975..20926147, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Microsomal triacylglycerol transfer protein Neighboring gene pseudo Neighboring gene Nth-like DNA glycosylase 1 Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial single-stranded DNA-binding protein from Drosophila embryos. Physical and biochemical characterization. Thömmes P, et al. J Biol Chem, 1995 Sep 8. PMID 7673145
    2. Purification and characterisation of a DNA helicase, dheI I, from Drosophila melanogaster embryos. Thömmes P, et al. Nucleic Acids Res, 1995 Nov 11. PMID 7501468, Free PMC Article
    3. Phosphorylation and localization of replication protein A during oogenesis and early embryogenesis of Drosophila melanogaster. Mitsis PG. Dev Biol, 1995 Aug. PMID 7649375
    4. Onset of the DNA replication checkpoint in the early Drosophila embryo. Crest J, et al. Genetics, 2007 Feb. PMID 17151243, Free PMC Article
    5. A new DNA polymerase species from Drosophila melanogaster: a probable mus308 gene product. Oshige M, et al. Mutat Res, 1999 Apr 9. PMID 10343651

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in chromosome, telomeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    replication protein A2
    Names
    CG9273-PA
    CG9273-PB
    RPA2-PA
    RPA2-PB
    drosophila replication protein A
    replication protein A 30
    replication protein A, subunit 2
    single stranded-binding protein 30

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20924975..20926147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136233.3 → NP_610077.1  replication protein A2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610077.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0MJ04, Q8T9K0, Q9VIH1
      Related
      FBpp0080967
      Conserved Domains (3) summary
      COG5235
      Location:12 → 246
      RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]
      cd04478
      Location:52 → 144
      RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...
      pfam08784
      Location:182 → 238
      RPA_C; Replication protein A C terminal

    2. NM_001273723.1 → NP_001260652.1  replication protein A2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0MJ04, Q8T9K0, Q9VIH1
      Conserved Domains (3) summary
      COG5235
      Location:12 → 246
      RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]
      cd04478
      Location:52 → 144
      RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...
      pfam08784
      Location:182 → 238
      RPA_C; Replication protein A C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SXG3 Q8SXG3
    Q9VIH1 Q9VIH1

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