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    dgt6 dim gamma-tubulin 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43441, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dgt6provided by FlyBase
    Official Full Name
    dim gamma-tubulin 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0039638
    Locus tag
    Dmel_CG11881
    See related
    AllianceGenome:FB:FBgn0039638
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11881; Dgt6; Dmel\CG11881; msd4
    Summary
    Enables protein-macromolecule adaptor activity. Involved in microtubule cytoskeleton organization and regulation of mitotic nuclear division. Located in spindle. Part of HAUS complex. Is expressed in organism. Orthologous to human HAUS6 (HAUS augmin like complex subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dgt6 in Genome Data Viewer
    Location:
    98F12-98F12; 3-97 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29128584..29130972, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24954306..24956694, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Autophagy-related 14 Neighboring gene yemanuclein Neighboring gene Choline transporter-like 2 Neighboring gene Vacuolar H[+] ATPase 100kD subunit 1 Neighboring gene Suppressor of ER stress-induced death Neighboring gene Alg13 UDP-N-acetylglucosaminyltransferase subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila histone variant H2A.V works in concert with HP1 to promote kinetochore-driven microtubule formation. Vernì F, et al. Cell Cycle, 2015. PMID 25591068, Free PMC Article
    2. Microcephaly protein Asp focuses the minus ends of spindle microtubules at the pole and within the spindle. Ito A, et al. J Cell Biol, 2015 Dec 7. PMID 26644514, Free PMC Article
    3. The role of Patronin in Drosophila mitosis. Pavlova GA, et al. BMC Mol Cell Biol, 2019 Apr 17. PMID 31284878, Free PMC Article
    4. Meiosis-specific stable binding of augmin to acentrosomal spindle poles promotes biased microtubule assembly in oocytes. Colombié N, et al. PLoS Genet, 2013 Jun. PMID 23785300, Free PMC Article
    5. γ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning. Bouissou A, et al. EMBO J, 2014 Jan 13. PMID 24421324, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitotic spindle-templated microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of HAUS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of HAUS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitotic spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dim gamma-tubulin 6
    Names
    CG11881-PA
    dgt6-PA
    mitotic spindle density 4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29128584..29130972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143414.4 → NP_651671.1  dim gamma-tubulin 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651671.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VAP2
      Related
      FBpp0084783
      Conserved Domains (1) summary
      pfam14661
      Location:21 → 257
      HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAP2.1 Q9VAP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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