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    Gbs-76A Glycogen binding subunit 76A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40102, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gbs-76Aprovided by FlyBase
    Official Full Name
    Glycogen binding subunit 76Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036862
    Locus tag
    Dmel_CG9619
    See related
    AllianceGenome:FB:FBgn0036862
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    149039_at; CG9619; Dmel\CG9619; GBS-76A
    Summary
    Enables protein phosphatase 1 binding activity. Predicted to be involved in negative regulation of glycogen catabolic process and positive regulation of glycogen biosynthetic process. Predicted to be part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to human PPP1R3A (protein phosphatase 1 regulatory subunit 3A) and PPP1R3D (protein phosphatase 1 regulatory subunit 3D). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gbs-76A in Genome Data Viewer
    Location:
    76A3-76A5; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19281364..19292766, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19274464..19285866, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46048 Neighboring gene falten Neighboring gene pipe

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of the glycogen binding subunit CG9238/Gbs-70E of protein phosphatase 1 in Drosophila melanogaster. Kerekes É, et al. Insect Biochem Mol Biol, 2014 Jun. PMID 24727027
    2. Inbreeding by environmental interactions affect gene expression in Drosophila melanogaster. Kristensen TN, et al. Genetics, 2006 Jul. PMID 16624914, Free PMC Article
    3. Dissection of Complex, Fitness-Related Traits in Multiple Drosophila Mapping Populations Offers Insight into the Genetic Control of Stress Resistance. Everman ER, et al. Genetics, 2019 Apr. PMID 30760490, Free PMC Article
    4. The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells. Landskron L, et al. Elife, 2018 Mar 27. PMID 29580384, Free PMC Article
    5. Towards a comprehensive analysis of the protein phosphatase 1 interactome in Drosophila. Bennett D, et al. J Mol Biol, 2006 Nov 24. PMID 17007873

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of glycogen catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of glycogen biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of protein phosphatase type 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glycogen binding subunit 76A
    Names
    CG9619-PA
    CG9619-PB
    CG9619-PC
    CG9619-PD
    Gbs-76A-PA
    Gbs-76A-PB
    Gbs-76A-PC
    Gbs-76A-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19281364..19292766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300189.1 → NP_001287118.1  glycogen binding subunit 76A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287118.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C3KGL1, Q8T0I8, Q9VVY3
      UniProtKB/TrEMBL
      M9PCY7
      Conserved Domains (1) summary
      pfam03370
      Location:526 → 631
      CBM_21; Carbohydrate/starch-binding module (family 21)

    2. NM_001275115.1 → NP_001262044.1  glycogen binding subunit 76A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262044.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C3KGL1, Q8T0I8, Q9VVY3
      UniProtKB/TrEMBL
      M9PCY7
      Conserved Domains (1) summary
      pfam03370
      Location:526 → 631
      CBM_21; Carbohydrate/starch-binding module (family 21)

    3. NM_001275114.1 → NP_001262043.1  glycogen binding subunit 76A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262043.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C3KGL1, Q8T0I8, Q9VVY3
      UniProtKB/TrEMBL
      M9PCY7
      Conserved Domains (1) summary
      pfam03370
      Location:526 → 631
      CBM_21; Carbohydrate/starch-binding module (family 21)

    4. NM_140847.2 → NP_649104.1  glycogen binding subunit 76A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649104.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C3KGL1, Q8T0I8, Q9VVY3
      UniProtKB/TrEMBL
      M9PCY7
      Related
      FBpp0074781
      Conserved Domains (1) summary
      pfam03370
      Location:526 → 631
      CBM_21; Carbohydrate/starch-binding module (family 21)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCY7 M9PCY7
    Q9VVY3.1 Q9VVY3

    Gene LinkOut

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