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    Cpsf73 Cleavage and polyadenylation specificity factor 73 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42240, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cpsf73provided by FlyBase
    Official Full Name
    Cleavage and polyadenylation specificity factor 73provided by FlyBase
    Primary source
    FLYBASE:FBgn0261065
    Locus tag
    Dmel_CG7698
    See related
    AllianceGenome:FB:FBgn0261065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7698; cpsf-73; CPSF-73; CPSF73; dCPSF-73; Dmel\CG7698
    Summary
    Predicted to enable 5'-3' RNA exonuclease activity; RNA binding activity; and RNA endonuclease activity. Involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway and mRNA 3'-end processing by stem-loop binding activity and cleavage. Part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Orthologous to human CPSF3 (cleavage and polyadenylation specific factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cpsf73 in Genome Data Viewer
    Location:
    91B8-91B8; 3-64 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18661121..18663552, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14486843..14489274, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene qin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cleavage stimulation factor 64 kD subunit Neighboring gene uncharacterized protein Neighboring gene Golgi SNARE, 28 kDa

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EM visualization of Pol II genes in Drosophila: most genes terminate without prior 3' end cleavage of nascent transcripts. Osheim YN, et al. Chromosoma, 2002 Mar. PMID 12068918
    2. In vivo characterization of the Drosophila mRNA 3' end processing core cleavage complex. Michalski D, et al. RNA, 2015 Aug. PMID 26081560, Free PMC Article
    3. Drosophila melanogaster retrotransposon and inverted repeat-derived endogenous siRNAs are differentially processed in distinct cellular locations. Harrington AW, et al. BMC Genomics, 2017 Apr 17. PMID 28415970, Free PMC Article
    4. Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors. Chen YA, et al. Mol Cell, 2016 Jul 7. PMID 27292797, Free PMC Article
    5. Protein composition of catalytically active U7-dependent processing complexes assembled on histone pre-mRNA containing biotin and a photo-cleavable linker. Skrajna A, et al. Nucleic Acids Res, 2018 May 18. PMID 29529248, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-3' RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA 3'-end processing by stem-loop binding and cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cleavage and polyadenylation specificity factor 73
    Names
    CG7698-PA
    Cpsf73-PA
    cleavage and polyadenylation specificity factor, 73kD-subunit
    NP_650738.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18661121..18663552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142481.3 → NP_650738.1  cleavage and polyadenylation specificity factor 73 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650738.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VE51
      Related
      FBpp0083105
      Conserved Domains (5) summary
      smart01027
      Location:252 → 373
      Beta-Casp; Beta-Casp domain
      smart01098
      Location:483 → 683
      CPSF73-100_C; This is the C-terminal conserved region of the pre-mRNA 3'-end-processing of the polyadenylation factor CPSF-73/CPSF-100 proteins
      COG1236
      Location:18 → 456
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:386 → 426
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16292
      Location:18 → 211
      CPSF3-like_MBL-fold; cleavage and polyadenylation specificity factor (CPSF) subunit 3 and related proteins; MBL-fold metallo-hydrolase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VE51.2 Q9VE51

    Gene LinkOut

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