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    LPCAT Lysophosphatidylcholine acyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31899, updated on 9-Dec-2024

    Summary

    Official Symbol
    LPCATprovided by FlyBase
    Official Full Name
    Lysophosphatidylcholine acyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052699
    Locus tag
    Dmel_CG32699
    See related
    AllianceGenome:FB:FBgn0052699
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15318; CG18535; CG2996; CG32699; CT7882; Dmel\CG32699; LPCAT1/2; tok-like
    Summary
    Enables lysophospholipid acyltransferase activity. Involved in lipid modification. Located in lipid droplet. Is expressed in adult head. Orthologous to several human genes including LPCAT1 (lysophosphatidylcholine acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See LPCAT in Genome Data Viewer
    Location:
    8E10-8E10; 1-28 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9571537..9579987, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9465570..9474020, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42767 Neighboring gene Cubilin Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45540 Neighboring gene long non-coding RNA:CR45541

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-acylglycerophosphocholine O-acyltransferase activity  
    enables O-acyltransferase activity  
    enables calcium ion binding  
    enables lysophosphatidic acid acyltransferase activity  
    enables lysophospholipid acyltransferase activity PubMed 
    Process Evidence Code Pubs
    involved_in lipid modification PubMed 
    involved_in phospholipid biosynthetic process  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in lipid droplet PubMed 

    General protein information

    Preferred Names
    lysophosphatidylcholine acyltransferase
    Names
    CG32699-PB
    LPCAT-PB
    Lyso-PA acyltransferase
    NP_001036265.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9571537..9579987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042800.3 → NP_001036265.1  lysophosphatidylcholine acyltransferase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036265.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0KHU5, Q86NX4, Q95SE4, Q9W331
      Conserved Domains (3) summary
      cd07991
      Location:126 → 338
      LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
      COG0204
      Location:87 → 265
      PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
      pfam13833
      Location:455 → 507
      EF-hand_8; EF-hand domain pair
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