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    Pkc98E Protein C kinase 98E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43428, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pkc98Eprovided by FlyBase
    Official Full Name
    Protein C kinase 98Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003093
    Locus tag
    Dmel_CG1954
    See related
    AllianceGenome:FB:FBgn0003093
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    98F; CG1954; Dmel\CG1954; Dpkc3; dPKC98F; Nc98F; nPKC; PK-C; PKC; PKC 98F; PKC d98F; PKC-98F; Pkc3; PKC98C; PKC98e; PKC98E
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including lipid droplet organization; long-term memory; and response to ethanol. Predicted to be located in plasma membrane. Is expressed in adult brain; adult head; and head. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to several human genes including PRKCE (protein kinase C epsilon). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pkc98E in Genome Data Viewer
    Location:
    98F6-98F6; 3-97 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29039156..29049148)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24864878..24874870)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45044 Neighboring gene beta1,4-N-acetylgalactosaminyltransferase B Neighboring gene Cleavage and polyadenylation specificity factor 100 Neighboring gene Slu7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ca(2+)-independent protein kinase Cs contain an amino-terminal domain similar to the C2 consensus sequence. Sossin WS, et al. Trends Biochem Sci, 1993 Jun. PMID 8346555
    2. Isolation and characterization of two new drosophila protein kinase C genes, including one specifically expressed in photoreceptor cells. Schaeffer E, et al. Cell, 1989 May 5. PMID 2720775
    3. Time-Dependent Odorant Sensitivity Modulation in Insects. Guo H, et al. Insects, 2022 Apr 2. PMID 35447796, Free PMC Article
    4. The SH2-like Akt homology (AH) domain of c-akt is present in multiple copies in the genome of vertebrate and invertebrate eucaryotes. Cloning and characterization of the Drosophila melanogaster c-akt homolog Dakt1. Franke TF, et al. Oncogene, 1994 Jan. PMID 8302573
    5. PKC98E Regulates Odorant Responses in Drosophila melanogaster. Poudel S, et al. J Neurosci, 2021 May 5. PMID 33789918, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PKC98E Regulates Odorant Responses in Drosophila melanogaster.
      Title: PKC98E Regulates Odorant Responses in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid droplet organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein C kinase 98E
    Names
    CG1954-PA
    CG1954-PB
    CG1954-PC
    CG1954-PD
    Neural-conserved-at-98F
    PKC-brain
    Pkc98E-PA
    Pkc98E-PB
    Pkc98E-PC
    Pkc98E-PD
    protein kinase C
    protein kinase-c3
    NP_001163767.1
    NP_001287576.1
    NP_001287577.1
    NP_524545.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29039156..29049148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079821.4 → NP_524545.2  protein C kinase 98E, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524545.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LHW0, P13678, Q9VAQ6
      Related
      FBpp0084728
      Conserved Domains (3) summary
      cd04014
      Location:1 → 134
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd05591
      Location:412 → 729
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:177 → 228
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    2. NM_001300647.1 → NP_001287576.1  protein C kinase 98E, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287576.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LI13
      Conserved Domains (4) summary
      cd04014
      Location:1 → 134
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      smart00220
      Location:407 → 664
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05591
      Location:411 → 728
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:177 → 228
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    3. NM_001170296.2 → NP_001163767.1  protein C kinase 98E, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163767.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4QQA3, Q95T78
      Conserved Domains (3) summary
      smart00220
      Location:223 → 480
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05591
      Location:227 → 544
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:67 → 119
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    4. NM_001300648.1 → NP_001287577.1  protein C kinase 98E, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LHW0, P13678, Q9VAQ6
      Conserved Domains (3) summary
      cd04014
      Location:1 → 134
      C2_PKC_epsilon; C2 domain in Protein Kinase C (PKC) epsilon
      cd05591
      Location:412 → 729
      STKc_nPKC_epsilon; Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon
      pfam00130
      Location:177 → 228
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LI13 A0A0B4LI13
    P13678.2 P13678
    Q4QQA3 Q4QQA3
    Q95T78 Q95T78

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