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    KIF4A kinesin family member 4A [ Homo sapiens (human) ]

    Gene ID: 24137, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KIF4Aprovided by HGNC
    Official Full Name
    kinesin family member 4Aprovided by HGNC
    Primary source
    HGNC:HGNC:13339
    See related
    Ensembl:ENSG00000090889 MIM:300521; AllianceGenome:HGNC:13339
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIF4; TMDI; KIF4G1; MRX100; XLID100
    Summary
    This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]
    Expression
    Broad expression in bone marrow (RPKM 4.3), lymph node (RPKM 2.9) and 14 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF4A in Genome Data Viewer
    Location:
    Xq13.1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (70290104..70420886)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (68723423..68854206)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69509954..69640736)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20889 Neighboring gene RAB41, member RAS oncogene family Neighboring gene PDZ domain containing 11 Neighboring gene TRAPPC2L pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:69622427-69622649 Neighboring gene RNY4 pseudogene 23 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:69642130-69643118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:69643119-69644107 Neighboring gene uncharacterized LOC105373244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:69655249-69655749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:69664203-69664989 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene RNA, U4 small nuclear 81, pseudogene Neighboring gene discs large MAGUK scaffold protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma. Huang Y, et al. Cell Death Dis, 2018 Feb 2. PMID 29396392, Free PMC Article
    2. Kinesin family member 4A: a potential predictor for progression of human oral cancer. Minakawa Y, et al. PLoS One, 2013. PMID 24386490, Free PMC Article
    3. Hepatitis B virus upregulates the expression of kinesin family member 4A. Zhu CL, et al. Mol Med Rep, 2015 Sep. PMID 25998931
    4. Chromokinesin: Kinesin superfamily regulating cell division through chromosome and spindle. Zhong A, et al. Gene, 2016 Sep 1. PMID 27196062
    5. Condensin I-mediated mitotic chromosome assembly requires association with chromokinesin KIF4A. Takahashi M, et al. Genes Dev, 2016 Sep 1. PMID 27633014, Free PMC Article

    See all (160) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of kinesin family member 4A inhibits cell proliferation, migration, and invasion while promoting apoptosis of urothelial bladder carcinoma cells.
      Title: Knockdown of kinesin family member 4A inhibits cell proliferation, migration, and invasion while promoting apoptosis of urothelial bladder carcinoma cells.
    2. KIF4A knockdown inhibits tumor progression and promotes chemo-sensitivity via induction of P21 in lung cancer cells.
      Title: KIF4A knockdown inhibits tumor progression and promotes chemo-sensitivity via induction of P21 in lung cancer cells.
    3. DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway.
      Title: DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway.
    4. KIF4A promotes genomic stability and progression of endometrial cancer through regulation of TPX2 protein degradation.
      Title: KIF4A promotes genomic stability and progression of endometrial cancer through regulation of TPX2 protein degradation.
    5. Bioinformatic and Experimental Analyses Reveal That KIF4A Is a Biomarker of Therapeutic Sensitivity and Predicts Prognosis in Cervical Cancer Patients.
      Title: Bioinformatic and Experimental Analyses Reveal That KIF4A Is a Biomarker of Therapeutic Sensitivity and Predicts Prognosis in Cervical Cancer Patients.
    6. Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
      Title: Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
    7. Kif4A mediates resistance to neoadjuvant chemoradiotherapy in patients with advanced colorectal cancer via regulating DNA damage response.
      Title: Kif4A mediates resistance to neoadjuvant chemoradiotherapy in patients with advanced colorectal cancer via regulating DNA damage response.
    8. KIF4A promotes tumor progression of bladder cancer via CXCL5 dependent myeloid-derived suppressor cells recruitment.
      Title: KIF4A promotes tumor progression of bladder cancer via CXCL5 dependent myeloid-derived suppressor cells recruitment.
    9. The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro.
      Title: The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro.
    10. EZH2 suppresses insulinoma development by epigenetically reducing KIF4A expression via H3K27me3 modification.
      Title: EZH2 suppresses insulinoma development by epigenetically reducing KIF4A expression via H3K27me3 modification.
    Submit: New GeneRIF Correction See all GeneRIFs (60)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual disability, X-linked 100
    MedGen: C3890167 OMIM: 300923 GeneReviews: Not available
    		Compare labs
    Taurodontism, microdontia, and dens invaginatus
    MedGen: C1839235 OMIM: 313490 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Deletion of residues 32-51 in the N-terminus of HIV-1 MA impairs both HIV-1 Gag interaction with KIF4 and its ability to induce microtubule (MT) acetylation, suggesting that MA-mediated targeting of KIF4 by Gag regulates MT stability in early infection PubMed
    gag Disrupting the function of KIF4 leads Gag transient accumulation in discrete, perinuclear, nonendocytic clusters that co-localize with endogenous KIF4, Ubc9, and SUMO PubMed
    gag Binding of HIV-1 Gag to KIF-4 may play a role in HIV-1 Gag polyprotein transport from the cytoplasm to the cell membrane PubMed
    gag Binding of human KIF-4 to HIV-1 Gag is presumed based on homology to murine KIF-4 which binds to an HIV-1 Gag intermediate, consisting of Matrix and Capsid, in a yeast two-hybrid assay and in co-immunoprecipitation assays PubMed
    matrix gag Deletion of residues 32-51 in the N-terminus of HIV-1 MA impairs both HIV-1 Gag interaction with KIF4 and its ability to induce microtubule (MT) acetylation, suggesting that MA-mediated targeting of KIF4 by Gag regulates MT stability in early infection PubMed
    gag Binding of HIV-1 Matrix to KIF-4 may play a role in HIV-1 Gag polyprotein relocalize from the cytoplasm to the cell membrane PubMed
    gag Binding of human KIF-4 to HIV-1 Matrix is presumed based on homology to murine KIF-4 which binds to an HIV-1 Gag intermediate, consisting of Matrix and Capsid, in a yeast two-hybrid assay and in co-immunoprecipitation assays PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12530, FLJ12655, FLJ14204, FLJ20631

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle midzone assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in organelle organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spindle elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in spindle microtubule TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chromosome-associated kinesin KIF4A
    Names
    chromokinesin KIF4A
    chromokinesin-A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016799.2 RefSeqGene

      Range
      5002..135784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_012310.5 → NP_036442.3  chromosome-associated kinesin KIF4A

      See identical proteins and their annotated locations for NP_036442.3

      Status: REVIEWED

      Source sequence(s)
      AL139398, AL357752
      Consensus CDS
      CCDS14401.1
      UniProtKB/Swiss-Prot
      B2R7V5, D3DVU4, O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3
      UniProtKB/TrEMBL
      Q59HG1
      Related
      ENSP00000363524.3, ENST00000374403.4
      Conserved Domains (4) summary
      COG1196
      Location:558 → 918
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:375 → 714
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01372
      Location:8 → 337
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam05033
      Location:1078 → 1120
      Pre-SET; Pre-SET motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      70290104..70420886
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      68723423..68854206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95239.3 GenPept UniProtKB/Swiss-Prot:O95239

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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