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    amx almondex [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43869, updated on 9-Dec-2024

    Summary

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    Official Symbol
    amxprovided by FlyBase
    Official Full Name
    almondexprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000077
    Locus tag
    Dmel_CG12127
    See related
    AllianceGenome:FB:FBgn0000077
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH02974; CG12127; Dmel\CG12127; fs(1)amx
    Summary
    Involved in several processes, including cell fate determination; lateral inhibition; and positive regulation of Notch signaling pathway. Predicted to be located in plasma membrane. Is expressed in organism. Used to study Alzheimer's disease. Orthologous to human TM2D3 (TM2 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See amx in Genome Data Viewer
    Location:
    8D2-8D2; 1-27 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9245915..9247336, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9139948..9141369, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 8a Neighboring gene mir-4916 stem loop Neighboring gene multi sex combs Neighboring gene La related protein 7 Neighboring gene Downstream of raf1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Studies of Genetic Variants Associated with Human Diseases in Notch Signaling-Related Genes Using Drosophila. Yang SA, et al. Methods Mol Biol, 2022. PMID 35674905, Free PMC Article
    2. The development of eggs produced by the female-sterile mutant almondex of Drosophila melanogaster. Shannon MP. J Exp Zool, 1973 Mar. PMID 4633255
    3. Characterization of the female-sterile mutant almondex of Drosophila melanogaster. Shannon MP. Genetica, 1972. PMID 4625164
    4. A cytogenetic analysis of the lozenge pseudoalleles in Drosophila. GREEN MM, et al. Z Indukt Abstamm Vererbungsl, 1956. PMID 13478080
    5. Partial rescue of embryos from two maternal-effect neurogenic mutants by transplantation of wild-type ooplasm. LaBonne SG, et al. Dev Biol, 1985 Jul. PMID 4007265

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TM2D genes regulate Notch signaling and neuronal function in Drosophila.
      Title: TM2D genes regulate Notch signaling and neuronal function in Drosophila.
    2. Maternal almondex, a neurogenic gene, is required for proper subcellular Notch distribution in early Drosophila embryogenesis.
      Title: Maternal almondex, a neurogenic gene, is required for proper subcellular Notch distribution in early Drosophila embryogenesis.
    3. we found that human TM2D3 expressed under the control of endogenous Drosophila amx regulatory elements is capable of rescuing the embryonic neurogenic phenotype, indicating that Amx and TM2D3 are orthologs and have conserved molecular functions in vivo
      Title: Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease.
    4. Our molecular data reveal that amx is ubiquitously expressed and encodes a conserved putative transmembrane protein, composed of several domains that are differently required for amx function in the fly.
      Title: Implication of the Drosophila beta-amyloid peptide binding-like protein AMX in Notch signaling during early neurogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in ectodermal cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lateral inhibition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lateral inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    almondex
    Names
    CG12127-PA
    CG12127-PB
    amx-PA
    amx-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9245915..9247336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079905.3 → NP_524644.1  almondex, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524644.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4H5, Q9W361
      UniProtKB/TrEMBL
      M9NF00
      Related
      FBpp0071266
      Conserved Domains (1) summary
      pfam05154
      Location:219 → 268
      TM2; TM2 domain

    2. NM_001258662.2 → NP_001245591.1  almondex, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245591.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U4H5, Q9W361
      UniProtKB/TrEMBL
      M9NF00
      Conserved Domains (1) summary
      pfam05154
      Location:219 → 268
      TM2; TM2 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NF00 M9NF00
    Q9U4H5.1 Q9U4H5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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