Ptpa Phosphotyrosyl phosphatase activator [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ptpaprovided by FlyBase
Official Full Name: Phosphotyrosyl phosphatase activatorprovided by FlyBase
Primary source: FLYBASE:FBgn0016698
Locus tag: Dmel_CG3289
See related: AllianceGenome:FB:FBgn0016698
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3289; Dmel\CG3289; DPTPA; ptpa; PTPA
Summary: Predicted to enable peptidyl-prolyl cis-trans isomerase activity and protein tyrosine phosphatase activator activity. Involved in basal protein localization and regulation of asymmetric protein localization involved in cell fate determination. Located in nucleus. Is expressed in adult head; larval brain; larval neurons; and organism. Used to study Parkinson's disease 25. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3377002..3378590)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3377002..3378590)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatase activator activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in basal protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of asymmetric protein localization involved in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ATPase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	ISS Inferred from Sequence or Structural Similarity more info

NP_523466.2

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The following sections contain reference sequences that belong to a specific genome build. Explain