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    CAB5 putative dephospho-CoA kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851777, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAB5
    Official Full Name
    putative dephospho-CoA kinase
    Primary source
    SGD:S000002604
    Locus tag
    YDR196C
    See related
    AllianceGenome:SGD:S000002604; FungiDB:YDR196C; VEuPathDB:YDR196C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable dephospho-CoA kinase activity. Involved in coenzyme A biosynthetic process. Located in lipid droplet. Is extrinsic component of mitochondrial outer membrane. Part of CoA-synthesizing protein complex. Used to study neurodegeneration with brain iron accumulation 6. Orthologous to human DCAKD (dephospho-CoA kinase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CAB5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (850274..850999, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RNA-processing protein REF2 Neighboring gene Cbs2p Neighboring gene protein-lysine N-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modeling human Coenzyme A synthase mutation in yeast reveals altered mitochondrial function, lipid content and iron metabolism. Ceccatelli Berti C, et al. Microb Cell, 2015 Apr 6. PMID 28357284, Free PMC Article
    2. Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. Olzhausen J, et al. FEMS Yeast Res, 2013 Sep. PMID 23789928
    3. Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Olzhausen J, et al. Curr Genet, 2009 Apr. PMID 19266201
    4. Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway. Olzhausen J, et al. Appl Microbiol Biotechnol, 2021 Oct. PMID 34491400, Free PMC Article
    5. Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. Daugherty M, et al. J Biol Chem, 2002 Jun 14. PMID 11923312

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dephospho-CoA kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dephospho-CoA kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dephospho-CoA kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coenzyme A biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CoA-synthesizing protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extrinsic component of mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative dephospho-CoA kinase
    NP_010482.3
    • Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; involved in histone acylation; null mutant lethality is complemented by human homologs DCAKD and COASY and by E. coli coaE (encoding DPCK); extrinsic component of the mitochondrial outer membrane that also localizes to lipid droplets

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      850274..850999 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180504.3 → NP_010482.3  TPA: putative dephospho-CoA kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010482.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSH9, Q03941
      UniProtKB/TrEMBL
      A6ZYF5, B3LG87, B5VG89, C7GN01, C8Z5B1, N1P4X9
      Conserved Domains (1) summary
      pfam01121
      Location:2 → 188
      CoaE; Dephospho-CoA kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03941.1

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