Rtf1 Rtf1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rtf1provided by FlyBase
Official Full Name: Rtf1provided by FlyBase
Primary source: FLYBASE:FBgn0034722
Locus tag: Dmel_CG10955
See related: AllianceGenome:FB:FBgn0034722
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10955; Dmel\CG10955; dRtf1; rtf1
Summary: Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in euchromatin and nucleus. Is expressed in spermatid and spermatocyte. Orthologous to human RTF1 (RTF1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22375090..22378484)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18262595..18265989)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

the dRtf1 component of the Paf1 complex functions in Notch signaling
Title: Drosophila Rtf1 functions in histone methylation, gene expression, and Notch signaling.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II C-terminal domain phosphoserine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cdc73/Paf1 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
located_in euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain