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    Pitslre pitslre [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40292, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pitslreprovided by FlyBase
    Official Full Name
    pitslreprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016696
    Locus tag
    Dmel_CG4268
    See related
    AllianceGenome:FB:FBgn0016696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdk11; CG4268; Dmel\CG4268; Gat; group 3; Gta; PitsIre; pitslre; PITSLRE
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Involved in positive regulation of Toll signaling pathway and positive regulation of antimicrobial peptide production. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; mesoderm; and presumptive embryonic/larval system. Orthologous to several human genes including CDK11B (cyclin dependent kinase 11B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pitslre in Genome Data Viewer
    Location:
    77E6-77E6; 3-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20771528..20776931)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20764628..20770031)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peroxin 16 Neighboring gene Peroxin 14 Neighboring gene Phosphorylated CTD-interacting factor 1 Neighboring gene antisense RNA:CR46484 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy. Wilkinson S, et al. Autophagy, 2011 Nov. PMID 21808150, Free PMC Article
    2. Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase. Biggs WH 3rd, et al. Proc Natl Acad Sci U S A, 1992 Jul 15. PMID 1378625, Free PMC Article
    3. Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase. Sauer K, et al. Mol Biol Cell, 1996 Nov. PMID 8930898, Free PMC Article
    4. A genome-wide survey of RS domain proteins. Boucher L, et al. RNA, 2001 Dec. PMID 11780626, Free PMC Article
    5. Dissecting the biological role of mucin-type O-glycosylation using RNA interference in Drosophila cell culture. Zhang L, et al. J Biol Chem, 2010 Nov 5. PMID 20807760, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of Toll signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pitslre
    Names
    CG4268-PA
    CG4268-PC
    CG4268-PE
    CG4268-PF
    CG4268-PG
    Galactosyltransferase-associated kinase-like
    Gat-like
    PITSLRE
    PITSLRE kinase
    Pitslre-PA
    Pitslre-PC
    Pitslre-PE
    Pitslre-PF
    Pitslre-PG
    NP_001246851.1
    NP_001246852.1
    NP_001262122.1
    NP_649251.2
    NP_730563.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20771528..20776931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140994.4 → NP_649251.2  pitslre, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649251.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5U100, Q8MQR7, Q94889, Q9TXB3, Q9VPC0
      Related
      FBpp0077905
      Conserved Domains (2) summary
      cd07843
      Location:552 → 851
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:555 → 854
      PLN00009; cyclin-dependent kinase A; Provisional

    2. NM_168869.3 → NP_730563.1  pitslre, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730563.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5U100, Q8MQR7, Q94889, Q9TXB3, Q9VPC0
      Related
      FBpp0077908
      Conserved Domains (2) summary
      cd07843
      Location:552 → 851
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:555 → 854
      PLN00009; cyclin-dependent kinase A; Provisional

    3. NM_001259923.2 → NP_001246852.1  pitslre, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246852.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFF6
      Conserved Domains (2) summary
      cd07843
      Location:378 → 677
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:381 → 680
      PLN00009; cyclin-dependent kinase A; Provisional

    4. NM_001275193.1 → NP_001262122.1  pitslre, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262122.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFF6
      Conserved Domains (2) summary
      cd07843
      Location:378 → 677
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:381 → 680
      PLN00009; cyclin-dependent kinase A; Provisional

    5. NM_001259922.2 → NP_001246851.1  pitslre, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246851.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFF6
      Conserved Domains (2) summary
      cd07843
      Location:378 → 677
      STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
      PLN00009
      Location:381 → 680
      PLN00009; cyclin-dependent kinase A; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3PFF6 D3PFF6
    Q9VPC0.1 Q9VPC0

    Gene LinkOut

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