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    Wdr37 WD repeat domain 37 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42218, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr37provided by FlyBase
    Official Full Name
    WD repeat domain 37provided by FlyBase
    Primary source
    FLYBASE:FBgn0038617
    Locus tag
    Dmel_CG12333
    See related
    AllianceGenome:FB:FBgn0038617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12333; Dmel\CG12333; wdr37
    Summary
    Is expressed in adult head and organism. Used to study neurooculocardiogenitourinary syndrome. Human ortholog(s) of this gene implicated in neurooculocardiogenitourinary syndrome. Orthologous to human WDR37 (WD repeat domain 37). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Wdr37 in Genome Data Viewer
    Location:
    91A5-91A6; 3-63 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18400373..18402716, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14226095..14228438, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase 100kD subunit 4 Neighboring gene corona Neighboring gene Vacuolar H[+] ATPase 100kD subunit 2 Neighboring gene Vesicle transport through interaction with t-SNAREs 1b Neighboring gene kokopelli Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia. Kanca O, et al. Am J Hum Genet, 2019 Aug 1. PMID 31327508, Free PMC Article
    2. Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K. Hyun S, et al. Cell, 2009 Dec 11. PMID 20005803
    3. Variant functional assessment in Drosophila by overexpression: what can we learn? Her Y, et al. Genome, 2024 Jun 1. PMID 38412472
    4. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article
    5. The Drosophila Helicase Maleless (MLE) is Implicated in Functions Distinct From its Role in Dosage Compensation. Cugusi S, et al. Mol Cell Proteomics, 2015 Jun. PMID 25776889, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    WD repeat domain 37
    Names
    CG12333-PA
    Wdr37-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18400373..18402716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142466.3 → NP_650723.1  WD repeat domain 37 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650723.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE73
      Related
      FBpp0083070
      Conserved Domains (3) summary
      COG2319
      Location:198 → 481
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:153 → 476
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:164 → 200
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VE73 Q9VE73

    Gene LinkOut

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