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    Ddrgk1 DDRGK domain containing 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42516, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ddrgk1provided by FlyBase
    Official Full Name
    DDRGK domain containing 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038868
    Locus tag
    Dmel_CG5862
    See related
    AllianceGenome:FB:FBgn0038868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5862; Dmel\CG5862
    Summary
    Predicted to enable ubiquitin-like protein ligase binding activity. Involved in protein ufmylation. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasmic side of endoplasmic reticulum membrane. Is expressed in adult head and organism. Orthologous to human DDRGK1 (DDRGK domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ddrgk1 in Genome Data Viewer
    Location:
    93C6-93C6; 3-71 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21215079..21216226)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17040801..17041948)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene SNF4/AMP-activated protein kinase gamma subunit Neighboring gene uncharacterized protein Neighboring gene Sensory neuron membrane protein 1 Neighboring gene pseudo Neighboring gene SET and MYND domain containing, class 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A neuroprotective role of Ufmylation through Atg9 in the aging brain of Drosophila. Li H, et al. Cell Mol Life Sci, 2023 Apr 22. PMID 37086384, Free PMC Article
    2. Natural variation of ebony gene controlling thoracic pigmentation in Drosophila melanogaster. Takahashi A, et al. Genetics, 2007 Oct. PMID 17660557, Free PMC Article
    3. Proteogenomics of Adenosine-to-Inosine RNA Editing in the Fruit Fly. Kuznetsova KG, et al. J Proteome Res, 2018 Nov 2. PMID 30298734
    4. A genetic screen in Drosophila for regulators of human prostate cancer progression. Ito S, et al. Biochem Biophys Res Commun, 2014 Sep 5. PMID 25117438
    5. Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Stempfl T, et al. Genetics, 2002 Feb. PMID 11861563, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables ubiquitin-like protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ufmylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasmic side of endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    DDRGK domain containing 1
    Names
    CG5862-PA
    Ddrgk1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21215079..21216226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142697.4 → NP_650954.1  DDRGK domain containing 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650954.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VDD1
      Related
      FBpp0083451
      Conserved Domains (1) summary
      pfam09756
      Location:109 → 296
      DDRGK; DDRGK domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDD1.1 Q9VDD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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