U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG2924 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31214, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG2924provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023528
    Locus tag
    Dmel_CG2924
    See related
    AllianceGenome:FB:FBgn0023528
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2924; EG:25E8.2; NICE5
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein K48-linked ubiquitination. Predicted to be active in nucleus. Is expressed in organism. Orthologous to several human genes including UBE2Q1 (ubiquitin conjugating enzyme E2 Q1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG2924 in Genome Data Viewer
    Location:
    2F2-2F3; 1-0.9 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2264657..2270761, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2158690..2164794, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tempura Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45480 Neighboring gene Grp170 co-chaperone Neighboring gene Vitelline membrane-like

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila. Cao W, et al. Genetics, 2008 Mar. PMID 18245849, Free PMC Article
    2. A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults. Parisi M, et al. Genome Biol, 2004. PMID 15186491, Free PMC Article
    3. Identification of downstream targets of the bone morphogenetic protein pathway in the Drosophila nervous system. Kim NC, et al. Dev Dyn, 2010 Sep. PMID 20652954
    4. Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteins. Jones D, et al. Genome Biol, 2002. PMID 11806825, Free PMC Article
    5. What was the set of ubiquitin and ubiquitin-like conjugating enzymes in the eukaryote common ancestor? Michelle C, et al. J Mol Evol, 2009 Jun. PMID 19452197, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG2924-PA
    CG2924-PB
    CG2924-PD
    CG2924-PE
    NP_001284819.1
    NP_001284820.1
    NP_569994.1
    NP_726805.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2264657..2270761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297890.1 → NP_001284819.1  uncharacterized protein Dmel_CG2924, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284819.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R09, Q86M59
      Conserved Domains (1) summary
      cd00195
      Location:224 → 349
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_166935.3 → NP_726805.1  uncharacterized protein Dmel_CG2924, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726805.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R09, Q86M59
      Related
      FBpp0070396
      Conserved Domains (1) summary
      cd00195
      Location:224 → 349
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    3. NM_130638.4 → NP_569994.1  uncharacterized protein Dmel_CG2924, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569994.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R09, Q86M59
      Related
      FBpp0290017
      Conserved Domains (1) summary
      cd00195
      Location:224 → 349
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    4. NM_001297891.1 → NP_001284820.1  uncharacterized protein Dmel_CG2924, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284820.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R09, Q86M59
      Conserved Domains (1) summary
      cd00195
      Location:224 → 349
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O46068 O46068
    Q29R09 Q29R09
    Q86M59 Q86M59
    Q8T3U4 Q8T3U4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous