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    Tif-IA Tif-IA [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35454, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Tif-IAprovided by FlyBase
    Official Full Name
    Tif-IAprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032988
    Locus tag
    Dmel_CG3278
    See related
    AllianceGenome:FB:FBgn0032988
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG16938; CG3278; CG5951; Dmel\CG3278; dTIF-IA; Tif-1a; Tif-1A; TIF-1A; TIf-IA; TIF-IA; tif1a; TIF1A; TifIA
    Summary
    Predicted to enable RNA polymerase I core binding activity and RNA polymerase I general transcription initiation factor activity. Involved in female germ-line stem cell population maintenance and nucleolar large rRNA transcription by RNA polymerase I. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; germline cell; gut section; and larval muscle cell. Orthologous to several human genes including RRN3 (RRN3 homolog, RNA polymerase I transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tif-IA in Genome Data Viewer
    Location:
    40F6-40F7; 2-54 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22249876..22258260)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22249876..22258260)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene NUBP iron-sulfur cluster assembly factor, mitochondrial Neighboring gene Ribosomal protein L21 Neighboring gene Meiosis regulator and mRNA stability factor 1 Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Ribosomal protein L5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An investigation of nutrient-dependent mRNA translation in Drosophila larvae. Nagarajan S, et al. Biol Open, 2014 Oct 10. PMID 25305039, Free PMC Article
    2. A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function. Wissel S, et al. G3 (Bethesda), 2016 Aug 9. PMID 27280787, Free PMC Article
    3. Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity. Martínez Corrales G, et al. Cell Rep, 2020 Feb 11. PMID 32049000, Free PMC Article
    4. Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development. Grewal SS, et al. Nat Cell Biol, 2005 Mar. PMID 15723055
    5. Evolution of gene expression and expression plasticity in long-term experimental populations of Drosophila melanogaster maintained under constant and variable ethanol stress. Yampolsky LY, et al. Mol Ecol, 2012 Sep. PMID 22774776, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role of Tif-1a in germline stem cells maintenance
      Title: A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function.
    2. muscle ribosome synthesis functions as a nutrient-dependent checkpoint for overall body growth: in nutrient rich conditions, TOR is required to maintain levels of TIF-IA and ribosome synthesis to promote high levels of systemic insulin
      Title: TIF-IA-dependent regulation of ribosome synthesis in drosophila muscle is required to maintain systemic insulin signaling and larval growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 22250953-22252544 mobile_element_type = transposon:FB{}2296
    • Loc: 22251245-22252270 mobile_element_type = transposon:1360{}548
    • Loc: 22255487-22256352 mobile_element_type = transposon:1360{}2312

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase I core binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase I general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase I general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in female germ-line stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleolar large rRNA transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase I promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase I promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase I promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tif-IA
    Names
    CG3278-PA
    Tif-IA-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      22249876..22258260
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176070.3 → NP_788084.1  Tif-IA [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788084.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RU9, Q9V9M5, Q9V9M6
      Related
      FBpp0085308
      Conserved Domains (1) summary
      pfam05327
      Location:40 → 553
      RRN3; RNA polymerase I specific transcription initiation factor RRN3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9M6 Q9V9M6

    Gene LinkOut

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