Cul1 Cullin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cul1provided by FlyBase
Official Full Name: Cullin 1provided by FlyBase
Primary source: FLYBASE:FBgn0015509
Locus tag: Dmel_CG1877
See related: AllianceGenome:FB:FBgn0015509
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1877; cul-1; Cul-1; cul1; CUL1; Cullin-1; Cullin1; dCul-1; dCul1; dCUL1; dmCUL1; Dmel\CG1877; l(2)02074; l(2)k01207; lin 19; Lin-19; lin-19/cul-1; lin19; Lin19; lin19-like; Q9V312
Summary: Enables ubiquitin ligase complex scaffold activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of neuron remodeling; and positive regulation of protein metabolic process. Located in nucleus. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; germline cell; imaginal disc; and mesoderm. Orthologous to human CUL1 (cullin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 43F1-43F2; 2-57 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7916856..7921579)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3804361..3809084)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease.
Title: CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease.
mutant larvae accumulate high levels of non-neddylated Cul1, suggesting that Int6 is a positive regulator of cullin neddylation
Title: The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila.
Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.
Title: Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin ligase complex scaffold activity	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of antimicrobial peptide production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptonemal complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein K11-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IC Inferred by Curator more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of cullin-RING ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cullin 1

Names: CG1877-PA; CG1877-PB; CG1877-PC; CG1877-PD; Cul1-PA; Cul1-PB; Cul1-PC; Cul1-PD; SCF-betaTrCP complex; cullin; cullin-1; cullin1; dCullin; dCullin1; lin-19-like; lin19-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

7916856..7921579

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165571.2 → NP_724623.1 cullin 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724623.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZ78, Q0E9G0, Q24311, Q9V312

UniProtKB/TrEMBL

D3DMX2

Related

FBpp0087921

Conserved Domains (3) summary

smart00182
Location:454 → 593

CULLIN; Cullin

smart00884
Location:701 → 765

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:21 → 669

Cullin; Cullin family
NM_165570.3 → NP_724622.1 cullin 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724622.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZ78, Q0E9G0, Q24311, Q9V312

UniProtKB/TrEMBL

D3DMX2

Related

FBpp0087922

Conserved Domains (3) summary

smart00182
Location:454 → 593

CULLIN; Cullin

smart00884
Location:701 → 765

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:21 → 669

Cullin; Cullin family
NM_165569.2 → NP_724621.1 cullin 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724621.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZ78, Q0E9G0, Q24311, Q9V312

UniProtKB/TrEMBL

D3DMX2

Related

FBpp0087923

Conserved Domains (3) summary

smart00182
Location:454 → 593

CULLIN; Cullin

smart00884
Location:701 → 765

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:21 → 669

Cullin; Cullin family
NM_078931.4 → NP_523655.1 cullin 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523655.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZ78, Q0E9G0, Q24311, Q9V312

UniProtKB/TrEMBL

D3DMX2

Related

FBpp0087924

Conserved Domains (3) summary

smart00182
Location:454 → 593

CULLIN; Cullin

smart00884
Location:701 → 765

Cullin_Nedd8; Cullin protein neddylation domain

pfam00888
Location:21 → 669

Cullin; Cullin family