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    Acer Angiotensin-converting enzyme-related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34189, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acerprovided by FlyBase
    Official Full Name
    Angiotensin-converting enzyme-relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016122
    Locus tag
    Dmel_CG10593
    See related
    AllianceGenome:FB:FBgn0016122
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACE; acer; ACER; CG10593; Dmel\CG10593; l(2)k07704
    Summary
    Enables peptidyl-dipeptidase activity. Involved in several processes, including heart morphogenesis; positive regulation of circadian sleep/wake cycle, sleep; and regulation of heart rate. Located in extracellular space. Is expressed in several structures, including adult fat body; adult head; embryonic/larval dorsal vessel; extraembryonic structure; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); heart valve disease (multiple); and lung disease (multiple). Orthologous to human ACE (angiotensin I converting enzyme). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Acer in Genome Data Viewer
    Location:
    29D4-29D4; 2-33 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8521933..8525740)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8521933..8525740)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Ubiquitin-like activating enzyme 4 Neighboring gene Sgroppino Neighboring gene lemming B Neighboring gene lemming A Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Aspartic acid-GTC 1-4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Acer gene of Drosophila codes for an angiotensin-converting enzyme homologue. Taylor CA, et al. Gene, 1996 Nov 28. PMID 8973330
    2. Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Rescue Memory Defects in Drosophila-Expressing Alzheimer's Disease-Related Transgenes Independently of the Canonical Renin Angiotensin System. Lee SH, et al. eNeuro, 2020 Nov-Dec. PMID 33060184, Free PMC Article
    3. Necessity of angiotensin-converting enzyme-related gene for cardiac functions and longevity of Drosophila melanogaster assessed by optical coherence tomography. Liao FT, et al. J Biomed Opt, 2014 Jan. PMID 24002232
    4. The Drosophila melanogaster-related angiotensin-I-converting enzymes Acer and Ance--distinct enzymic characteristics and alternative expression during pupal development. Houard X, et al. Eur J Biochem, 1998 Nov 1. PMID 9839949
    5. Conserved roles for peptidases in the processing of invertebrate neuropeptides. Isaac RE, et al. Biochem Soc Trans, 2000. PMID 10961940

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Acer disrupts the normal response of sleep to changes in nutrition. Other nutrient-sensitive phenotypes, including survival and glycogen storage, were also altered in the Acer mutant but lipid storage was not.
      Title: Loss of angiotensin-converting enzyme-related (ACER) peptidase disrupts behavioural and metabolic responses to diet in Drosophila melanogaster.
    2. Loss of Angiotensin-converting enzyme-related (ACER) peptidase disrupts night-time sleep in adult Drosophila melanogaster.
      Title: Loss of Angiotensin-converting enzyme-related (ACER) peptidase disrupts night-time sleep in adult Drosophila melanogaster.
    3. may have a role in specification of heart progenitors in Drosophila embryos
      Title: Angiotensin-converting enzyme 2 is an essential regulator of heart function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metallopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidyl-dipeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Angiotensin-converting enzyme-related
    Names
    Acer-PA
    Acer-PB
    Angiotensin-converting enzyme peptidase
    CG10593-PA
    CG10593-PB
    angiotensin-converting enzyme-related
    NP_001260258.1
    NP_477195.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8521933..8525740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273329.1 → NP_001260258.1  Angiotensin-converting enzyme-related, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260258.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24222, Q9VLJ6
      UniProtKB/TrEMBL
      M9PCE8
      Conserved Domains (1) summary
      cd06461
      Location:37 → 605
      M2_ACE; Peptidase family M2 Angiotensin converting enzyme (ACE)

    2. NM_057847.4 → NP_477195.1  Angiotensin-converting enzyme-related, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477195.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24222, Q9VLJ6
      UniProtKB/TrEMBL
      M9PCE8
      Related
      FBpp0079297
      Conserved Domains (1) summary
      cd06461
      Location:37 → 605
      M2_ACE; Peptidase family M2 Angiotensin converting enzyme (ACE)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCE8 M9PCE8
    Q9VLJ6.1 Q9VLJ6

    Gene LinkOut

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