Git G protein-coupled receptor kinase interacting ArfGAP [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gitprovided by FlyBase
Official Full Name: G protein-coupled receptor kinase interacting ArfGAPprovided by FlyBase
Primary source: FLYBASE:FBgn0033539
Locus tag: Dmel_CG16728
See related: AllianceGenome:FB:FBgn0033539
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: arfgap2; CG16728; CT37209; dgit; dGit; Dmel\CG16728; git; GIT
Summary: Enables molecular adaptor activity. Involved in several processes, including mushroom body development; positive regulation of hippo signaling; and protein localization to presynapse. Located in cell leading edge; cytoplasm; and presynaptic active zone. Colocalizes with cytoskeleton of presynaptic active zone. Is expressed in several structures, including adult head; dorsal pharyngeal muscle primordium; larval muscle cell; larval muscle system; and somatic muscle primordium. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to several human genes including GIT2 (GIT ArfGAP 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (10641818..10645427, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (6529323..6532932, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The results indicate that the dPix-Git complex controls egg chamber morphogenesis by controlling myosin contractility and Pak kinase downstream of focal adhesions.
Title: The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development.
Pix and Git regulate Hippo-pathway-dependent tissue growth.
Title: The GTPase regulatory proteins Pix and Git control tissue growth via the Hippo pathway.
GIT regulates stoned B levels and synaptic vesicle recycling.
Title: A presynaptic role for the cytomatrix protein GIT in synaptic vesicle recycling.
dGIT (CG16728) and dPak are part of a complex that promotes proper muscle morphogenesis and myotube targeting during embryogenesis.
Title: The Drosophila homologue of Arf-GAP GIT1, dGIT, is required for proper muscle morphogenesis and guidance during embryogenesis.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISM Inferred from Sequence Model more info	PubMed
enables molecular adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IEA Inferred from Electronic Annotation more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of organ growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ARF protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ARF protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle recycling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoskeleton of presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

Names: CG16728-PA; G-protein-coupled receptor kinase-interacting protein; Git-PA

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The following sections contain reference sequences that belong to a specific genome build. Explain