Sirt7 Sirtuin 7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Sirt7provided by FlyBase
Official Full Name: Sirtuin 7provided by FlyBase
Primary source: FLYBASE:FBgn0039631
Locus tag: Dmel_CG11305
See related: AllianceGenome:FB:FBgn0039631
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11305; D.mel5; Dmel\CG11305; dmSRT409; dSIRT7; SIRT7
Summary: Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Predicted to be involved in epigenetic regulation of gene expression. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in spermatozoon. Orthologous to human SIRT7 (sirtuin 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29055927..29059204)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (24881649..24884926)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Preparation of polyclonal antibodies against the Drosophila deacetylases SIRT 6 and SIRT 7.
Title: Preparation of polyclonal antibodies against the Drosophila deacetylases SIRT 6 and SIRT 7.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables histone H3K18 deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity, NAD-dependent	NAS Non-traceable Author Statement more info	PubMed
enables protein-glutaryllysine deglutarylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-succinyllysine desuccinylase activity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain