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    Rft1 RFT1 homolog [ Mus musculus (house mouse) ]

    Gene ID: 328370, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rft1provided by MGI
    Official Full Name
    RFT1 homologprovided by MGI
    Primary source
    MGI:MGI:3607791
    See related
    Ensembl:ENSMUSG00000052395 AllianceGenome:MGI:3607791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D930025H04
    Summary
    Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process and glycolipid translocation. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal gland; brain; cardiovascular system; genitourinary system; and gut. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation In. Orthologous to human RFT1 (RFT1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 5.2), subcutaneous fat pad adult (RPKM 4.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rft1 in Genome Data Viewer
    Location:
    14 B; 14 18.9 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30375041..30413274)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30654340..30691317)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2422 Neighboring gene predicted gene, 52147 Neighboring gene protein kinase C, delta Neighboring gene STARR-positive B cell enhancer ABC_E7301 Neighboring gene predicted gene, 53839 Neighboring gene STARR-positive B cell enhancer ABC_E4101 Neighboring gene STARR-positive B cell enhancer ABC_E1892 Neighboring gene STARR-seq mESC enhancer starr_36309 Neighboring gene Scm-like with four mbt domains 1 Neighboring gene RIKEN cDNA 1700087M22 gene Neighboring gene transformer 2 beta homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glycolipid translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolipid translocation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycolipid translocation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1; protein RFT1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001425843.1 → NP_001412772.1  man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154436, AC154646
      UniProtKB/TrEMBL
      B7ZP34

    2. NM_001425844.1 → NP_001412773.1  man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154436, AC154646
      UniProtKB/TrEMBL
      B7ZP34

    3. NM_001425845.1 → NP_001412774.1  man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154436, AC154646
      UniProtKB/TrEMBL
      B7ZP34

    4. NM_001425846.1 → NP_001412775.1  man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154436, AC154646

    5. NM_001425847.1 → NP_001412776.1  man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154436, AC154646

    6. NM_177815.4 → NP_808483.2  man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 1

      See identical proteins and their annotated locations for NP_808483.2

      Status: VALIDATED

      Source sequence(s)
      AC154436, AC154646
      Consensus CDS
      CCDS26896.1
      UniProtKB/Swiss-Prot
      B2RUN9, Q8C3B8
      UniProtKB/TrEMBL
      B7ZP34
      Related
      ENSMUSP00000064153.8, ENSMUST00000064230.16
      Conserved Domains (1) summary
      pfam04506
      Location:11 → 524
      Rft-1; Rft protein

    RNA

    1. NR_189624.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154436, AC154646

    2. NR_189625.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154436, AC154646
      Related
      ENSMUST00000228686.2

    3. NR_189626.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154436, AC154646

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      30375041..30413274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316058.3 → XP_017171547.1  protein RFT1 homolog isoform X1

      Conserved Domains (1) summary
      cl09326
      Location:9 → 261
      MATE_like; Multidrug and toxic compound extrusion family and similar proteins

    RNA

    1. XR_001781128.3 RNA Sequence

    2. XR_383188.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C3B8.2 GenPept UniProtKB/Swiss-Prot:Q8C3B8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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