Tcf21 transcription factor 21 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tcf21provided by MGI
Official Full Name: transcription factor 21provided by MGI
Primary source: MGI:MGI:1202715
See related: Ensembl:ENSMUSG00000045680 AllianceGenome:MGI:1202715
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: epc; Pod1; Pod-1; bHLHa23; capsulin; epicardin
Summary: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and E-box binding activity. Involved in several processes, including metanephros development; regulation of transcription by RNA polymerase II; and skeletal muscle organ development. Acts upstream of or within several processes, including lung development; nephron development; and sex determination. Part of transcription regulator complex. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; heart and pericardium; and respiratory system. Human ortholog(s) of this gene implicated in coronary artery disease and ventricular septal defect. Orthologous to human TCF21 (transcription factor 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in bladder adult (RPKM 101.3), lung adult (RPKM 85.6) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A3; 10 10.33 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (22693162..22696042, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (22817263..22820143, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factor Tcf21 modulates urinary bladder size and differentiation.
Title: Transcription factor Tcf21 modulates urinary bladder size and differentiation.
Single cell G-protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21.
Title: Single cell G-protein coupled receptor profiling of activated kidney fibroblasts expressing transcription factor 21.
Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6/STAT3 signaling pathway and the interplay between VSMCs and ECs.
Title: Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6/STAT3 signaling pathway and the interplay between VSMCs and ECs.
Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development.
Title: Tcf21 marks visceral adipose mesenchymal progenitors and functions as a rate-limiting factor during visceral adipose tissue development.
Novel TCF21[high] pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix.
Title: Novel TCF21(high) pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix.
Stromal Transcription Factor 21 Regulates Development of the Renal Stroma via Interaction with Wnt/beta-Catenin Signaling.
Title: Stromal Transcription Factor 21 Regulates Development of the Renal Stroma via Interaction with Wnt/β-Catenin Signaling.
Studies on the Role of the Transcription Factor Tcf21 in the Transdifferentiation of Parietal Epithelial Cells into Podocyte-Like Cells.
Title: Studies on the Role of the Transcription Factor Tcf21 in the Transdifferentiation of Parietal Epithelial Cells into Podocyte-Like Cells.
TCF21(+) mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice.
Title: TCF21(+) mesenchymal cells contribute to testis somatic cell development, homeostasis, and regeneration in mice.
A Deactivation Factor of Fibrogenic Hepatic Stellate Cells Induces Regression of Liver Fibrosis in Mice.
Title: A Deactivation Factor of Fibrogenic Hepatic Stellate Cells Induces Regression of Liver Fibrosis in Mice.
After E15.5, Tcf21 progenitor cells exclusively become lipofibroblasts and interstitial fibroblasts. Lipid metabolism genes were highly expressed in perinatal and adult Tcf21 lineage cells. Overexpression of Tcf21 in primary neonatal lung fibroblasts led to increases in intracellular neutral lipids, suggesting a regulatory role for Tcf21 in lipofibroblast function.
Title: The Tcf21 lineage constitutes the lung lipofibroblast population.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tcf21 (e-PCR), detects polymorphism
- UniSTS:464696

Spp1 (e-PCR), detects polymorphism
- UniSTS:498509

Tcf21 (e-PCR), detects polymorphism
- UniSTS:498511

Tcf21 (e-PCR), detects polymorphism
- UniSTS:547825

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables bHLH transcription factor binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear androgen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Sertoli cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in Sertoli cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in branchiomeric skeletal muscle development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within bronchiole development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diaphragm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryonic digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic digestive tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gland development	ISO Inferred from Sequence Orthology more info
involved_in gland development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric glomerular capillary formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metanephric mesenchymal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within morphogenesis of a branching structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of androgen receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within reproductive structure development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within respiratory system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in roof of mouth development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spleen development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor 21

Names: podocyte-expressed 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011545.2 → NP_035675.1 transcription factor 21

Status: VALIDATED

Source sequence(s)

AF035717, AK011575

Consensus CDS

CCDS23732.1

UniProtKB/Swiss-Prot

O35437, Q3U023

UniProtKB/TrEMBL

A0A1W2P7S0

Related

ENSMUSP00000053178.8, ENSMUST00000049930.9

Conserved Domains (1) summary

pfam00010
Location:80 → 132

HLH; Helix-loop-helix DNA-binding domain