Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pik3ap1provided by MGI
Official Full Name: phosphoinositide-3-kinase adaptor protein 1provided by MGI
Primary source: MGI:MGI:1933177
See related: Ensembl:ENSMUSG00000025017 AllianceGenome:MGI:1933177
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BCAP; 1810044J04Rik
Summary: Enables identical protein binding activity and phosphatidylinositol 3-kinase regulatory subunit binding activity. Involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; regulation of inflammatory response; and regulation of innate immune response. Located in cytosol and plasma membrane. Orthologous to human PIK3AP1 (phosphoinositide-3-kinase adaptor protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 20.9), liver adult (RPKM 11.8) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 34.61 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (41260980..41373541, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (41272541..41385102, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BCAP Regulates Dendritic Cell Maturation Through the Dual-Regulation of NF-kappaB and PI3K/AKT Signaling During Infection.
Title: BCAP Regulates Dendritic Cell Maturation Through the Dual-Regulation of NF-κB and PI3K/AKT Signaling During Infection.
B-cell phosphoinositide 3-kinase adapter protein 1 (BCAP) delayed the recruitment and activation of pro-caspase-1 within the NLRP3/ASC preinflammasome through its association with Flightless-1, suggesting BCAP is a multifunctional signaling adaptor that inhibits key pathogen-sensing pathways in macrophages.
Title: The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1.
a novel role for BCAP in promoting TLR-induced IFN-alpha production in pDC and in systemic lupus erythematosus pathogenesis.
Title: Cutting Edge: BCAP Promotes Lupus-like Disease and TLR-Mediated Type I IFN Induction in Plasmacytoid Dendritic Cells.
BCAP is critical for IL-1R-induced phosphoinositide 3-kinase-Akt-mechanistic target of rapamycin (mTOR) activation, and minimal inhibition of mTOR completely abrogated IL-1beta-induced differentiation of pathogenic Th17 cells, mimicking BCAP deficiency.
Title: BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation.
induction of BCAP serves as a positive feedback circuit to enhance PI3K signaling in activated CD8(+) T cells, thereby acting as a molecular checkpoint regulating effector and memory T cell development.
Title: B cell adaptor for PI3-kinase (BCAP) modulates CD8(+) effector and memory T cell differentiation.
we showed that BCAP plays an important role in osteoclast differentiation
Title: BCAP promotes osteoclast differentiation through regulation of the p38-dependent CREB signaling pathway.
identify BCAP as a novel inhibitor of myelopoiesis in the steady state and of emergency myelopoiesis during demand conditions
Title: BCAP inhibits proliferation and differentiation of myeloid progenitors in the steady state and during demand situations.
Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.
Title: Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.
BCAP is a unique TIR domain-containing toll like receptor (TLR) signaling adapter crucial for linking TLRs to PI3K activation and regulating the inflammatory response.
Title: Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt.
BCAP is an essential activator of the PI3K pathway downstream of TLR signaling.
Title: B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D19Mit119 (e-PCR), detects polymorphism
- UniSTS:128333

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol 3-kinase regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor 2 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor 4 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor 7 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in toll-like receptor 9 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphoinositide 3-kinase adapter protein 1

Names: B cell phosphoinositide 3-kinase adaptor; B-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.