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    Nkain3 Na+/K+ transporting ATPase interacting 3 [ Mus musculus (house mouse) ]

    Gene ID: 269513, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nkain3provided by MGI
    Official Full Name
    Na+/K+ transporting ATPase interacting 3provided by MGI
    Primary source
    MGI:MGI:2444830
    See related
    Ensembl:ENSMUSG00000055761 AllianceGenome:MGI:2444830
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C530048M05; E130310K16Rik
    Summary
    Predicted to be involved in regulation of sodium ion transport. Located in membrane. Is expressed in central nervous system and retina. Orthologous to human NKAIN3 (sodium/potassium transporting ATPase interacting 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 2.5), CNS E18 (RPKM 2.2) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nkain3 in Genome Data Viewer
    Location:
    4 A3; 4 7.82 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (20111029..20779990, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (20111029..20780709, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene small cell adhesion glycoprotein pseudogene Neighboring gene STARR-seq mESC enhancer starr_09708 Neighboring gene STARR-positive B cell enhancer mm9_chr4:20118894-20119195 Neighboring gene gamma-glutamyl hydrolase Neighboring gene STARR-seq mESC enhancer starr_09709 Neighboring gene predicted gene, 52761 Neighboring gene STARR-seq mESC enhancer starr_09710 Neighboring gene predicted gene 11872 Neighboring gene tubulin, alpha 4A pseudogene Neighboring gene STARR-seq mESC enhancer starr_09711 Neighboring gene STARR-seq mESC enhancer starr_09712 Neighboring gene STARR-seq mESC enhancer starr_09713 Neighboring gene STARR-seq mESC enhancer starr_09714 Neighboring gene STARR-seq mESC enhancer starr_09715 Neighboring gene STARR-seq mESC enhancer starr_09716 Neighboring gene STARR-seq mESC enhancer starr_09718 Neighboring gene core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_09719 Neighboring gene STARR-seq mESC enhancer starr_09721 Neighboring gene predicted gene, 25977

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3
    Names
    Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290410.1 → NP_001277339.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001277339.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK141456, BC075683, CR931798
      Consensus CDS
      CCDS71349.1
      UniProtKB/Swiss-Prot
      A2ANL4, A6MHP8, A6MHQ0, Q3URJ8, Q6DI91, Q8BPL2, Q8C7P6
      Related
      ENSMUSP00000113113.2, ENSMUST00000119374.8
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 177
      NKAIN; Na,K-Atpase Interacting protein

    2. NM_172987.2 → NP_766575.2  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform 2

      See identical proteins and their annotated locations for NP_766575.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC075683
      Consensus CDS
      CCDS17997.1
      UniProtKB/Swiss-Prot
      Q3URJ8
      Related
      ENSMUSP00000100063.4, ENSMUST00000102998.4
      Conserved Domains (1) summary
      pfam05640
      Location:10 → 158
      NKAIN; Na,K-Atpase Interacting protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      20111029..20779990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537951.5 → XP_006538014.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform X1

      Conserved Domains (1) summary
      pfam05640
      Location:10 → 198
      NKAIN; Na,K-Atpase Interacting protein

    2. XM_011250046.4 → XP_011248348.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform X2

      Conserved Domains (1) summary
      pfam05640
      Location:10 → 198
      NKAIN; Na,K-Atpase Interacting protein

    3. XM_011250047.3 → XP_011248349.1  sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3 isoform X3

      Conserved Domains (1) summary
      pfam05640
      Location:10 → 159
      NKAIN; Na,K-Atpase Interacting protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3URJ8.1 GenPept UniProtKB/Swiss-Prot:Q3URJ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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