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    Erlec1 endoplasmic reticulum lectin 1 [ Mus musculus (house mouse) ]

    Gene ID: 66753, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Erlec1provided by MGI
    Official Full Name
    endoplasmic reticulum lectin 1provided by MGI
    Primary source
    MGI:MGI:1914003
    See related
    Ensembl:ENSMUSG00000020311 AllianceGenome:MGI:1914003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933407N01Rik
    Summary
    Predicted to enable unfolded protein binding activity. Predicted to be involved in negative regulation of retrograde protein transport, ER to cytosol and retrograde protein transport, ER to cytosol. Predicted to be active in endoplasmic reticulum lumen. Is expressed in mandible; maxilla; orbito-sphenoid; and rib. Orthologous to human ERLEC1 (endoplasmic reticulum lectin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 3.4), bladder adult (RPKM 3.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Erlec1 in Genome Data Viewer
    Location:
    11 A4; 11 18.18 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (30812794..30904385, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (30862794..30954386, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29068 Neighboring gene predicted gene 12100 Neighboring gene STARR-seq mESC enhancer starr_29070 Neighboring gene proteasome (prosome, macropain) activator subunit 4 Neighboring gene spindle and kinetochore-associated protein 2 pseudogene Neighboring gene G protein-coupled receptor 75 Neighboring gene PDZ and LIM domain protein 1 pseudogene Neighboring gene ankyrin repeat and SOCS box-containing 3 Neighboring gene ChaC, cation transport regulator 2 Neighboring gene GPN-loop GTPase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition. Cruciat CM, et al. J Biol Chem, 2006 May 5. PMID 16531414
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Erlectin functions in N-glycan recognition in the endoplasmic reticulum and may regulate glycoprotein traffic
      Title: The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ERAD pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum lectin 1
    Names
    ER lectin
    erlectin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025745.3 → NP_080021.3  endoplasmic reticulum lectin 1 precursor

      See identical proteins and their annotated locations for NP_080021.3

      Status: VALIDATED

      Source sequence(s)
      AK133874, AL662891
      Consensus CDS
      CCDS24509.1
      UniProtKB/Swiss-Prot
      Q3UZF3, Q8BVN6, Q8VEH8
      UniProtKB/TrEMBL
      Q9CWA6
      Related
      ENSMUSP00000072929.8, ENSMUST00000073192.14
      Conserved Domains (2) summary
      pfam07915
      Location:342 → 421
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:206 → 250
      PRKCSH; Glucosidase II beta subunit-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      30812794..30904385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243744.3 → XP_011242046.1  endoplasmic reticulum lectin 1 isoform X3

      UniProtKB/TrEMBL
      Q9CWA6
      Conserved Domains (2) summary
      pfam07915
      Location:342 → 421
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:206 → 250
      PRKCSH; Glucosidase II beta subunit-like protein

    2. XM_011243743.4 → XP_011242045.1  endoplasmic reticulum lectin 1 isoform X2

      UniProtKB/TrEMBL
      Q9CWA6
      Conserved Domains (2) summary
      pfam07915
      Location:342 → 421
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:206 → 250
      PRKCSH; Glucosidase II beta subunit-like protein

    3. XM_030246233.2 → XP_030102093.1  endoplasmic reticulum lectin 1 isoform X1

      UniProtKB/TrEMBL
      Q9CWA6
      Conserved Domains (2) summary
      pfam07915
      Location:342 → 421
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:206 → 250
      PRKCSH; Glucosidase II beta subunit-like protein

    4. XM_006514781.4 → XP_006514844.1  endoplasmic reticulum lectin 1 isoform X4

      UniProtKB/TrEMBL
      Q9CWA6
      Conserved Domains (2) summary
      pfam07915
      Location:342 → 421
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:206 → 250
      PRKCSH; Glucosidase II beta subunit-like protein

    5. XM_030246234.2 → XP_030102094.1  endoplasmic reticulum lectin 1 isoform X6

      Conserved Domains (2) summary
      pfam07915
      Location:158 → 237
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:22 → 66
      PRKCSH; Glucosidase II beta subunit-like protein

    6. XM_006514782.5 → XP_006514845.1  endoplasmic reticulum lectin 1 isoform X5

      UniProtKB/TrEMBL
      Q9CWA6
      Conserved Domains (2) summary
      pfam07915
      Location:342 → 421
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:206 → 250
      PRKCSH; Glucosidase II beta subunit-like protein

    7. XM_030246235.2 → XP_030102095.1  endoplasmic reticulum lectin 1 isoform X7

      Conserved Domains (2) summary
      pfam07915
      Location:158 → 237
      PRKCSH; Glucosidase II beta subunit-like protein
      cl06793
      Location:22 → 66
      PRKCSH; Glucosidase II beta subunit-like protein

    RNA

    1. XR_004937005.1 RNA Sequence

    2. XR_003949491.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEH8.1 GenPept UniProtKB/Swiss-Prot:Q8VEH8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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