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    Rps6kc1 ribosomal protein S6 kinase polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 320119, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rps6kc1provided by MGI
    Official Full Name
    ribosomal protein S6 kinase polypeptide 1provided by MGI
    Primary source
    MGI:MGI:2443419
    See related
    Ensembl:ENSMUSG00000089872 AllianceGenome:MGI:2443419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rpk118; B130003F20Rik
    Summary
    Predicted to enable ATP binding activity; phosphatidylinositol binding activity; and protein kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Is active in postsynaptic density. Is expressed in olfactory epithelium and vomeronasal organ. Orthologous to human RPS6KC1 (ribosomal protein S6 kinase C1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 3.4), CNS E14 (RPKM 3.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rps6kc1 in Genome Data Viewer
    Location:
    1 H6; 1 96.2 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (190505076..190645207, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (190772879..190913010, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38452 Neighboring gene STARR-seq mESC enhancer starr_03419 Neighboring gene predicted gene, 39738 Neighboring gene STARR-seq mESC enhancer starr_03421 Neighboring gene predicted gene, 51740 Neighboring gene STARR-positive B cell enhancer mm9_chr1:192705345-192705646 Neighboring gene STARR-positive B cell enhancer ABC_E3353 Neighboring gene angel homolog 2 Neighboring gene predicted gene, 53493 Neighboring gene vasohibin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
    2. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase delta-1
    Names
    52 kDa ribosomal protein S6 kinase
    S6K-delta-1
    ribosomal protein S6 kinase, 52kDa, polypeptide 1
    NP_848890.3
    XP_006497235.1
    XP_006497236.1
    XP_006497237.1
    XP_006497238.1
    XP_011237223.1
    XP_030110821.1
    XP_030110822.1
    XP_036021590.1
    XP_036021591.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178775.4 → NP_848890.3  ribosomal protein S6 kinase delta-1

      Status: VALIDATED

      Source sequence(s)
      AK149858, BC058403, BG079911, CJ045347
      UniProtKB/Swiss-Prot
      Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
      UniProtKB/TrEMBL
      E9QMX4
      Related
      ENSMUSP00000061769.9, ENSMUST00000061611.15
      Conserved Domains (5) summary
      cd07287
      Location:11 → 128
      PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
      smart00220
      Location:864 → 1046
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd02677
      Location:237 → 309
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:869 → 1046
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:334 → 427
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      190505076..190645207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497172.4 → XP_006497235.1  ribosomal protein S6 kinase delta-1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
      Conserved Domains (4) summary
      cd02677
      Location:225 → 297
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:857 → 1034
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl02563
      Location:11 → 116
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:322 → 415
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006497175.4 → XP_006497238.1  ribosomal protein S6 kinase delta-1 isoform X4

      UniProtKB/Swiss-Prot
      Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
      Conserved Domains (4) summary
      cd07287
      Location:11 → 128
      PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
      cd05576
      Location:749 → 926
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl00299
      Location:155 → 189
      MIT; domain contained within Microtubule Interacting and Trafficking molecules. The MIT domain is found in sorting nexins, the nuclear thiol protease PalBH, the AAA protein spastin and archaebacterial proteins with similar domain architecture, vacuolar ...
      cl21453
      Location:214 → 307
      PKc_like; Protein Kinases, catalytic domain

    3. XM_006497173.4 → XP_006497236.1  ribosomal protein S6 kinase delta-1 isoform X2

      UniProtKB/Swiss-Prot
      Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
      Conserved Domains (4) summary
      cd07287
      Location:11 → 128
      PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
      cd02677
      Location:237 → 309
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:838 → 1015
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:305 → 396
      PKc_like; Protein Kinases, catalytic domain

    4. XM_006497174.4 → XP_006497237.1  ribosomal protein S6 kinase delta-1 isoform X3

      UniProtKB/Swiss-Prot
      Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
      Conserved Domains (3) summary
      cd07287
      Location:11 → 128
      PX_RPK118_like; The phosphoinositide binding Phox Homology domain of RPK118-like proteins
      cd02677
      Location:237 → 309
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cl21453
      Location:869 → 960
      PKc_like; Protein Kinases, catalytic domain

    5. XM_030254962.1 → XP_030110822.1  ribosomal protein S6 kinase delta-1 isoform X6

      Conserved Domains (3) summary
      cd02677
      Location:56 → 128
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:657 → 834
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:124 → 215
      PKc_like; Protein Kinases, catalytic domain

    6. XM_030254961.1 → XP_030110821.1  ribosomal protein S6 kinase delta-1 isoform X5

      UniProtKB/Swiss-Prot
      Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
      Conserved Domains (3) summary
      cd02677
      Location:56 → 128
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:688 → 865
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:153 → 246
      PKc_like; Protein Kinases, catalytic domain

    7. XM_011238921.2 → XP_011237223.1  ribosomal protein S6 kinase delta-1 isoform X5

      UniProtKB/Swiss-Prot
      Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
      Conserved Domains (3) summary
      cd02677
      Location:56 → 128
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:688 → 865
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:153 → 246
      PKc_like; Protein Kinases, catalytic domain

    8. XM_036165697.1 → XP_036021590.1  ribosomal protein S6 kinase delta-1 isoform X5

      UniProtKB/Swiss-Prot
      Q3UDY3, Q6PDY4, Q8BLK9, Q8BMQ5, Q8BX49
      Conserved Domains (3) summary
      cd02677
      Location:56 → 128
      MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
      cd05576
      Location:688 → 865
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
      cl21453
      Location:153 → 246
      PKc_like; Protein Kinases, catalytic domain

    9. XM_036165698.1 → XP_036021591.1  ribosomal protein S6 kinase delta-1 isoform X7

      Conserved Domains (1) summary
      cd05576
      Location:434 → 611
      STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

    RNA

    1. XR_004942884.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLK9.2 GenPept UniProtKB/Swiss-Prot:Q8BLK9

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