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    Tdrp testis development related protein [ Mus musculus (house mouse) ]

    Gene ID: 72148, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tdrpprovided by MGI
    Official Full Name
    testis development related proteinprovided by MGI
    Primary source
    MGI:MGI:1919398
    See related
    Ensembl:ENSMUSG00000050052 AllianceGenome:MGI:1919398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610019F03Rik
    Summary
    Predicted to be involved in spermatogenesis. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; ileum; immune system; reproductive system; and trigeminal nerve. Orthologous to human TDRP (testis development related protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 15.0), genital fat pad adult (RPKM 14.6) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tdrp in Genome Data Viewer
    Location:
    8 A1.1; 8 6.44 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (14002008..14025484, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13952008..13975478, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr8:13907572-13907873 Neighboring gene interferon induced transmembrane protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20776 Neighboring gene F-box protein 25 Neighboring gene STARR-seq mESC enhancer starr_20780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13992606-13992862 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:13996330-13996563 Neighboring gene predicted gene 5907 Neighboring gene predicted gene, 53401 Neighboring gene STARR-seq mESC enhancer starr_20785 Neighboring gene glutamate rich 1 Neighboring gene predicted gene, 57788

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells. Piras G, et al. Brain Behav Immun, 2020 Jul. PMID 32126289
    2. TDRP deficiency contributes to low sperm motility and is a potential risk factor for male infertility. Mao S, et al. Am J Transl Res, 2016. PMID 27069551, Free PMC Article
    3. Molecular cloning of a novel nuclear factor, TDRP1, in spermatogenic cells of testis and its relationship with spermatogenesis. Wang X, et al. Biochem Biophys Res Commun, 2010 Mar 26. PMID 20170638
    4. 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry. Berggård T, et al. J Proteome Res, 2006 Mar. PMID 16512683
    5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    testis development-related protein
    Names
    immuno-moodulin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361625.2 → NP_001348554.1  testis development-related protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC139186
      UniProtKB/TrEMBL
      B7ZNJ7
      Conserved Domains (1) summary
      pfam15683
      Location:45 → 190
      TDRP; Testis development-related protein

    2. NM_001361628.2 → NP_001348557.1  testis development-related protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC139186
      Consensus CDS
      CCDS22119.1
      UniProtKB/Swiss-Prot
      Q3TQC8, Q8C5P7
      Conserved Domains (1) summary
      pfam15683
      Location:38 → 182
      TDRP; Testis development-related protein

    3. NM_001361629.2 → NP_001348558.1  testis development-related protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC139186
      Consensus CDS
      CCDS22119.1
      UniProtKB/Swiss-Prot
      Q3TQC8, Q8C5P7
      Conserved Domains (1) summary
      pfam15683
      Location:38 → 182
      TDRP; Testis development-related protein

    4. NM_001361630.2 → NP_001348559.1  testis development-related protein isoform b

      Status: VALIDATED

      Source sequence(s)
      AC139186
      Consensus CDS
      CCDS22119.1
      UniProtKB/Swiss-Prot
      Q3TQC8, Q8C5P7
      Conserved Domains (1) summary
      pfam15683
      Location:38 → 182
      TDRP; Testis development-related protein

    5. NM_173744.5 → NP_776105.1  testis development-related protein isoform b

      See identical proteins and their annotated locations for NP_776105.1

      Status: VALIDATED

      Source sequence(s)
      AC139186
      Consensus CDS
      CCDS22119.1
      UniProtKB/Swiss-Prot
      Q3TQC8, Q8C5P7
      Related
      ENSMUSP00000058371.5, ENSMUST00000062613.12
      Conserved Domains (1) summary
      pfam15683
      Location:38 → 182
      TDRP; Testis development-related protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      14002008..14025484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242083.4 → XP_011240385.1  testis development-related protein isoform X1

      Conserved Domains (1) summary
      pfam15683
      Location:109 → 254
      TDRP; Testis development-related protein

    2. XM_011242084.2 → XP_011240386.1  testis development-related protein isoform X2

      See identical proteins and their annotated locations for XP_011240386.1

      Conserved Domains (1) summary
      pfam15683
      Location:57 → 202
      TDRP; Testis development-related protein

    3. XM_011242085.4 → XP_011240387.1  testis development-related protein isoform X2

      See identical proteins and their annotated locations for XP_011240387.1

      Conserved Domains (1) summary
      pfam15683
      Location:57 → 202
      TDRP; Testis development-related protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C5P7.1 GenPept UniProtKB/Swiss-Prot:Q8C5P7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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