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    Tmem91 transmembrane protein 91 [ Mus musculus (house mouse) ]

    Gene ID: 320208, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem91provided by MGI
    Official Full Name
    transmembrane protein 91provided by MGI
    Primary source
    MGI:MGI:2443589
    See related
    Ensembl:ENSMUSG00000061702 AllianceGenome:MGI:2443589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DSPC3; SynDIG3; A830041P22Rik
    Summary
    Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be active in intracellular membrane-bounded organelle and membrane. Orthologous to human TMEM91 (transmembrane protein 91). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 3.3), frontal lobe adult (RPKM 2.4) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem91 in Genome Data Viewer
    Location:
    7 A3; 7 13.97 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25368564..25379011, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25669139..25679623, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57782 Neighboring gene branched chain ketoacid dehydrogenase E1, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E8156 Neighboring gene STARR-positive B cell enhancer ABC_E10430 Neighboring gene STARR-seq mESC enhancer starr_18309 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26443819-26444002 Neighboring gene STARR-positive B cell enhancer ABC_E696 Neighboring gene exosome component 5 Neighboring gene STARR-positive B cell enhancer ABC_E9022 Neighboring gene STARR-positive B cell enhancer ABC_E6524 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26466931-26467040 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26468633-26468786 Neighboring gene B9 protein domain 2 Neighboring gene transforming growth factor, beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development. Kalashnikova E, et al. Neuron, 2010 Jan 14. PMID 20152115, Free PMC Article
    2. The dispanins: a novel gene family of ancient origin that contains 14 human members. Sällman Almén M, et al. PLoS One, 2012. PMID 22363774, Free PMC Article
    3. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article
    4. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 91
    Names
    dispanin subfamily C member 3
    synapse differentiation-induced protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290497.1 → NP_001277426.1  transmembrane protein 91 isoform 2

      See identical proteins and their annotated locations for NP_001277426.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK079312, BC058996, BQ555196
      Consensus CDS
      CCDS71918.1
      UniProtKB/TrEMBL
      D3Z7E7
      Related
      ENSMUSP00000104042.2, ENSMUST00000108405.2
      Conserved Domains (1) summary
      pfam04505
      Location:92 → 124
      CD225; Interferon-induced transmembrane protein

    2. NM_001290498.1 → NP_001277427.1  transmembrane protein 91 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC162614, AK079312, BC058996, BE863748
      Consensus CDS
      CCDS80681.1
      UniProtKB/TrEMBL
      D3Z7E8
      Related
      ENSMUSP00000104041.2, ENSMUST00000108404.8
      Conserved Domains (1) summary
      pfam04505
      Location:92 → 120
      CD225; Interferon-induced transmembrane protein

    3. NM_177102.4 → NP_796076.1  transmembrane protein 91 isoform 1

      See identical proteins and their annotated locations for NP_796076.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK079312, BC058996
      Consensus CDS
      CCDS39840.1
      UniProtKB/Swiss-Prot
      Q8C581
      Related
      ENSMUSP00000078407.4, ENSMUST00000079439.10
      Conserved Domains (1) summary
      pfam04505
      Location:92 → 158
      CD225; Interferon-induced transmembrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      25368564..25379011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540068.5 → XP_006540131.1  transmembrane protein 91 isoform X1

      See identical proteins and their annotated locations for XP_006540131.1

      UniProtKB/Swiss-Prot
      Q8C581
      Conserved Domains (1) summary
      pfam04505
      Location:92 → 158
      CD225; Interferon-induced transmembrane protein

    2. XM_006540073.5 → XP_006540136.1  transmembrane protein 91 isoform X3

      Conserved Domains (1) summary
      pfam04505
      Location:92 → 120
      CD225; Interferon-induced transmembrane protein

    3. XM_030242676.2 → XP_030098536.1  transmembrane protein 91 isoform X2

      UniProtKB/TrEMBL
      D3Z7E7
      Conserved Domains (1) summary
      pfam04505
      Location:92 → 124
      CD225; Interferon-induced transmembrane protein

    4. XM_006540069.5 → XP_006540132.1  transmembrane protein 91 isoform X1

      See identical proteins and their annotated locations for XP_006540132.1

      UniProtKB/Swiss-Prot
      Q8C581
      Conserved Domains (1) summary
      pfam04505
      Location:92 → 158
      CD225; Interferon-induced transmembrane protein

    5. XM_006540067.5 → XP_006540130.1  transmembrane protein 91 isoform X1

      See identical proteins and their annotated locations for XP_006540130.1

      UniProtKB/Swiss-Prot
      Q8C581
      Conserved Domains (1) summary
      pfam04505
      Location:92 → 158
      CD225; Interferon-induced transmembrane protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C581.1 GenPept UniProtKB/Swiss-Prot:Q8C581

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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