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    Elmod2 ELMO/CED-12 domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 244548, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Elmod2provided by MGI
    Official Full Name
    ELMO/CED-12 domain containing 2provided by MGI
    Primary source
    MGI:MGI:2445165
    See related
    Ensembl:ENSMUSG00000035151 AllianceGenome:MGI:2445165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830169G11Rik
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of defense response to virus. Is expressed in several structures, including adrenal gland; genitourinary system; gut gland; nervous system; and stomach. Orthologous to human ELMOD2 (ELMO domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 5.0), CNS E18 (RPKM 5.0) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Elmod2 in Genome Data Viewer
    Location:
    8 C2; 8 39.72 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84039261..84059115, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83312632..83332490, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 9 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22078 Neighboring gene uncoupling protein 1 (mitochondrial, proton carrier) Neighboring gene STARR-seq mESC enhancer starr_22080 Neighboring gene STARR-positive B cell enhancer ABC_E1762 Neighboring gene predicted gene, 32327 Neighboring gene MGAT4 family, member C Neighboring gene cofilin 1, non-muscle pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis. Turn RE, et al. Mol Biol Cell, 2020 Aug 15. PMID 32614697, Free PMC Article
    2. GTPase-activating protein Elmod2 is essential for meiotic progression in mouse oocytes. Zhou CX, et al. Cell Cycle, 2017 May 3. PMID 28324667, Free PMC Article
    3. Roles for ELMOD2 and Rootletin in ciliogenesis. Turn RE, et al. Mol Biol Cell, 2021 Apr 15. PMID 33596093, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Roles for ELMOD2 and Rootletin in ciliogenesis.
      Title: Roles for ELMOD2 and Rootletin in ciliogenesis.
    2. The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis.
      Title: The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis.
    3. Elmod2 is the GTPase-activating protein essential to meiosis progression of mouse oocytes, most likely by regulating mitochondrial dynamics.
      Title: GTPase-activating protein Elmod2 is essential for meiotic progression in mouse oocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ELMO domain-containing protein 2
    Names
    ELMO domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170691.1 → NP_001164162.1  ELMO domain-containing protein 2

      See identical proteins and their annotated locations for NP_001164162.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122890, AK036607
      Consensus CDS
      CCDS22450.1
      UniProtKB/Swiss-Prot
      Q6AXC7, Q8BGF6, Q8BHP5
      Related
      ENSMUSP00000137044.2, ENSMUST00000177594.8
      Conserved Domains (1) summary
      pfam04727
      Location:110 → 268
      ELMO_CED12; ELMO/CED-12 family

    2. NM_178736.5 → NP_848851.3  ELMO domain-containing protein 2

      See identical proteins and their annotated locations for NP_848851.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122890, AK084950
      Consensus CDS
      CCDS22450.1
      UniProtKB/Swiss-Prot
      Q6AXC7, Q8BGF6, Q8BHP5
      Related
      ENSMUSP00000052287.4, ENSMUST00000053902.4
      Conserved Domains (1) summary
      pfam04727
      Location:110 → 268
      ELMO_CED12; ELMO/CED-12 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84039261..84059115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154033.1 → XP_036009926.1  ELMO domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q6AXC7, Q8BGF6, Q8BHP5
      Conserved Domains (1) summary
      pfam04727
      Location:110 → 268
      ELMO_CED12; ELMO/CED-12 family

    2. XM_006530979.4 → XP_006531042.1  ELMO domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006531042.1

      UniProtKB/Swiss-Prot
      Q6AXC7, Q8BGF6, Q8BHP5
      Conserved Domains (1) summary
      pfam04727
      Location:110 → 268
      ELMO_CED12; ELMO/CED-12 family

    RNA

    1. XR_004934824.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGF6.1 GenPept UniProtKB/Swiss-Prot:Q8BGF6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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