Slc5a8 solute carrier family 5 (iodide transporter), member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc5a8provided by MGI
Official Full Name: solute carrier family 5 (iodide transporter), member 8provided by MGI
Primary source: MGI:MGI:2384916
See related: Ensembl:ENSMUSG00000020062 AllianceGenome:MGI:2384916
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ait; SMCT
Summary: Enables lactate transmembrane transporter activity; monocarboxylate:sodium symporter activity; and propionate transmembrane transporter activity. Involved in nicotinate transport. Acts upstream of or within propanoate transmembrane transport. Located in apical plasma membrane. Part of GINS complex. Is expressed in olfactory epithelium and rectum. Orthologous to human SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 27.7), large intestine adult (RPKM 16.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 44.34 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (88721854..88765377)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (88885992..88929515)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis.
Title: Monocarboxylate transporter functions and neuroprotective effects of valproic acid in experimental models of amyotrophic lateral sclerosis.
Reducing monocarboxylate transporter MCT1 worsens experimental diabetic peripheral neuropathy.
Title: Reducing monocarboxylate transporter MCT1 worsens experimental diabetic peripheral neuropathy.
Transport characteristics of 5-aminosalicylic acid into colonic epithelium: Involvement of sodium-coupled monocarboxylate transporter SMCT1-mediated transport system.
Title: Transport characteristics of 5-aminosalicylic acid into colonic epithelium: Involvement of sodium-coupled monocarboxylate transporter SMCT1-mediated transport system.
Slc5a8 is an obligatory link between dietary fibre and mucosal immune system via the bacterial metabolite butyrate and that this transporter is a conditional tumour suppressor in colon linked to dietary fibre content.
Title: Slc5a8, a Na+-coupled high-affinity transporter for short-chain fatty acids, is a conditional tumour suppressor in colon that protects against colitis and colon cancer under low-fibre dietary conditions.
Data indicate oncogenic HRAS (HRAS(G12V)) as a potent mediator of SLC5A8 silencing in human nontransformed normal mammary epithelial cell lines and in mouse mammary tumors through DNMT1.
Title: Molecular mechanism of SLC5A8 inactivation in breast cancer.
Efficacy of LP or their secreted soluble factors to stimulate SMCT1 expression and function and to counteract the inhibitory effects of TNF-alpha on butyrate absorption could have potential therapeutic value.
Title: The probiotic Lactobacillus plantarum counteracts TNF-{alpha}-induced downregulation of SMCT1 expression and function.
butyrate and propionate block the generation of dendritic cells from bone marrow stem cells, since Slc5a8 transports butyrate and propionate into cells, and these two bacterial metabolites inhibit histone deacetylases
Title: Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases.
Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.
Title: Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.
In conventional mice with normal bacterial colonization of the intestinal tract, GPR109A and SLC5A8 are expressed on the apical membrane of epithelial cells lining the ileum and colon.
Title: Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate transporter SLC5A8.
CDX1 and CDX2 bind the promoter region of SLC5A8 and up-regulate its expression in cultured cells and in colonic epithelium.
Title: CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

General gene information

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Markers

Slc5a8 (e-PCR), detects polymorphism
- UniSTS:547354

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lactate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monocarboxylate:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monocarboxylate:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables organic acid:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables organic acid:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables propionate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables short-chain fatty acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in acetate transport	ISO Inferred from Sequence Orthology more info
involved_in acetate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in iodide transport	ISO Inferred from Sequence Orthology more info
involved_in iodide transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in lactate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in lactate transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monocarboxylic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nicotinate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nicotinate transport	ISO Inferred from Sequence Orthology more info
involved_in nitrate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in nitrate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in propanoate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within propanoate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in propanoate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyruvate transport	ISO Inferred from Sequence Orthology more info
involved_in pyruvate transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within short-chain fatty acid transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GINS complex	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in brush border membrane	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: sodium-coupled monocarboxylate transporter 1

Names: electrogenic sodium monocarboxylate cotransporter; solute carrier family 5 member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145423.2 → NP_663398.2 sodium-coupled monocarboxylate transporter 1

See identical proteins and their annotated locations for NP_663398.2

Status: VALIDATED

Source sequence(s)

AY484428

Consensus CDS

CCDS36026.1

UniProtKB/Swiss-Prot

Q8BYF6, Q8VD01

Related

ENSMUSP00000020255.7, ENSMUST00000020255.8

Conserved Domains (1) summary

cd11519
Location:7 → 549

SLC5sbd_SMCT1; Na(+)/monocarboxylate cotransporter SMCT1 and related proteins; solute-binding domain