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    Cimip2b ciliary microtubule inner protein 2B [ Mus musculus (house mouse) ]

    Gene ID: 329831, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cimip2bprovided by MGI
    Official Full Name
    ciliary microtubule inner protein 2Bprovided by MGI
    Primary source
    MGI:MGI:2445194
    See related
    Ensembl:ENSMUSG00000042788 AllianceGenome:MGI:2445194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam166b; 4833436C18Rik
    Summary
    Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in lung. Orthologous to human CIMIP2B (ciliary microtubule inner protein 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 3.3), stomach adult (RPKM 2.3) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cimip2b in Genome Data Viewer
    Location:
    4 A5; 4 23.03 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43427014..43431451, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43427014..43432131, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ATPase, class I, type 8B, member 5 Neighboring gene predicted gene, 46850 Neighboring gene STARR-seq mESC enhancer starr_10051 Neighboring gene RUN and SH3 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_10053 Neighboring gene predicted gene, 52698 Neighboring gene testis specific protein kinase 1 Neighboring gene CD72 antigen Neighboring gene STARR-positive B cell enhancer ABC_E2109 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:43495064-43495217 Neighboring gene suppression inducing transmembrane adaptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Chen Z, et al. Cell, 2023 Nov 9. PMID 37865089, Free PMC Article
    2. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ciliary microtubule inner protein 2B
    Names
    family with sequence similarity 166, member B
    protein FAM166B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162381.1 → NP_001155853.1  ciliary microtubule inner protein 2B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 3' coding region that results in a frameshift, compared to variant 1, and a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK029435, AK053208
      Consensus CDS
      CCDS51163.1
      UniProtKB/TrEMBL
      E9Q4G6
      Related
      ENSMUSP00000127145.3, ENSMUST00000171134.9
      Conserved Domains (1) summary
      pfam10629
      Location:16 → 82
      DUF2475; Protein of unknown function (DUF2475)

    2. NM_001369077.1 → NP_001356006.1  ciliary microtubule inner protein 2B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL732506
      Consensus CDS
      CCDS89735.1
      UniProtKB/Swiss-Prot
      A2AIP0, A2AIP2, B0R005, B0R006, Q8C6T2, Q8CDW8
      Related
      ENSMUSP00000103562.4, ENSMUST00000107929.10
      Conserved Domains (1) summary
      pfam10629
      Location:16 → 45
      DUF2475; Protein of unknown function (DUF2475)

    3. NM_177377.5 → NP_796351.2  ciliary microtubule inner protein 2B isoform 1

      See identical proteins and their annotated locations for NP_796351.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK029435, AK053208
      Consensus CDS
      CCDS51162.1
      UniProtKB/Swiss-Prot
      A2AIP0
      Related
      ENSMUSP00000058980.4, ENSMUST00000052829.10
      Conserved Domains (1) summary
      pfam10629
      Location:16 → 85
      DUF2475; Protein of unknown function (DUF2475)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      43427014..43431451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538011.5 → XP_006538074.1  ciliary microtubule inner protein 2B isoform X1

      See identical proteins and their annotated locations for XP_006538074.1

      UniProtKB/Swiss-Prot
      A2AIP0
      Conserved Domains (1) summary
      pfam10629
      Location:16 → 85
      DUF2475; Protein of unknown function (DUF2475)

    2. XM_006538012.5 → XP_006538075.1  ciliary microtubule inner protein 2B isoform X3

      See identical proteins and their annotated locations for XP_006538075.1

      UniProtKB/Swiss-Prot
      A2AIP0, A2AIP2, B0R005, B0R006, Q8C6T2, Q8CDW8
      Conserved Domains (1) summary
      pfam10629
      Location:16 → 45
      DUF2475; Protein of unknown function (DUF2475)

    3. XM_011250054.4 → XP_011248356.1  ciliary microtubule inner protein 2B isoform X2

      Conserved Domains (1) summary
      pfam10629
      Location:16 → 85
      DUF2475; Protein of unknown function (DUF2475)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AIP0.1 GenPept UniProtKB/Swiss-Prot:A2AIP0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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