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    Cd200l1 CD200 molecule like 1 [ Mus musculus (house mouse) ]

    Gene ID: 208166, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cd200l1provided by MGI
    Official Full Name
    CD200 molecule like 1provided by MGI
    Primary source
    MGI:MGI:2685455
    See related
    Ensembl:ENSMUSG00000053182 AllianceGenome:MGI:2685455
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm609; iSEC2; isec1; Gm1749
    Summary
    Predicted to enable cell-cell adhesion mediator activity. Predicted to be involved in heterotypic cell-cell adhesion and negative regulation of neuroinflammatory response. Predicted to be active in axon; cell surface; and neuronal cell body. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in large intestine adult (RPKM 2.1), colon adult (RPKM 1.0) and 10 other tissues See more
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    Genomic context

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    See Cd200l1 in Genome Data Viewer
    Location:
    16 B5; 16 29.53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45232130..45313367, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (45411767..45493004, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30760 Neighboring gene STARR-positive B cell enhancer mm9_chr16:45390029-45390330 Neighboring gene CD200 molecule Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene ankyrin repeat domain 35 pseudogene Neighboring gene CD200 molecule like 2 Neighboring gene TNF receptor associated factor 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R. Kojima T, et al. Sci Rep, 2016 Nov 7. PMID 27819346, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in heterotypic cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuroinflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC208166
    Names
    913020L22Rik
    iSEC1 protein, intestinal secretory cell protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005854.2 → NP_001005854.2  uncharacterized protein LOC208166

      See identical proteins and their annotated locations for NP_001005854.2

      Status: VALIDATED

      Source sequence(s)
      AC117783, AC124636
      Consensus CDS
      CCDS28197.2
      UniProtKB/TrEMBL
      A0A077K8V5, E9Q573
      Related
      ENSMUSP00000110233.3, ENSMUST00000114585.3
      Conserved Domains (1) summary
      cd05846
      Location:26 → 120
      Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      45232130..45313367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245855.2 → XP_011244157.1  uncharacterized protein LOC208166 isoform X2

      See identical proteins and their annotated locations for XP_011244157.1

      UniProtKB/TrEMBL
      A0A077K8V5, E9Q573
      Conserved Domains (1) summary
      cd05846
      Location:26 → 120
      Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar domains

    2. XM_011245854.2 → XP_011244156.1  uncharacterized protein LOC208166 isoform X1

      UniProtKB/TrEMBL
      A0A077K8V5
      Conserved Domains (1) summary
      cd05846
      Location:38 → 132
      Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar domains

    3. XM_036159835.1 → XP_036015728.1  uncharacterized protein LOC208166 isoform X3

      UniProtKB/TrEMBL
      A0A077K8V5
      Conserved Domains (1) summary
      cd05846
      Location:26 → 133
      IgV_1_MRC-OX-2_like; First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains
    Nucleotide Protein Strain
    Heading Accession and Version

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