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    Tomm5 translocase of outer mitochondrial membrane 5 [ Mus musculus (house mouse) ]

    Gene ID: 68512, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tomm5provided by MGI
    Official Full Name
    translocase of outer mitochondrial membrane 5provided by MGI
    Primary source
    MGI:MGI:1915762
    See related
    Ensembl:ENSMUSG00000078713 AllianceGenome:MGI:1915762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tom5; 1110019J04Rik
    Summary
    Predicted to be involved in protein targeting to mitochondrion. Located in mitochondrion. Orthologous to human TOMM5 (translocase of outer mitochondrial membrane 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 56.7), liver E14.5 (RPKM 53.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tomm5 in Genome Data Viewer
    Location:
    4 B1; 4 23.72 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45105209..45108113, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45105209..45108113, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10090 Neighboring gene polymerase (RNA) I polypeptide E Neighboring gene F-box protein 10 Neighboring gene predicted gene, 30939 Neighboring gene STARR-seq mESC enhancer starr_10091 Neighboring gene FERM and PDZ domain containing 1 Neighboring gene FERM and PDZ domain containing 1, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45309913-45310096 Neighboring gene tRNA methyltransferase 10B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cryptogenic organizing pneumonia in Tomm5(-/-) mice. Vogel P, et al. Vet Pathol, 2013 Jan. PMID 22688586
    2. Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane. Kato H, et al. Biochem Biophys Res Commun, 2008 May 9. PMID 18331822
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in protein targeting to mitochondrion IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial outer membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial outer membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial outer membrane translocase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import receptor subunit TOM5 homolog
    Names
    translocase of outer mitochondrial membrane 5 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099675.1 → NP_001093145.1  mitochondrial import receptor subunit TOM5 homolog isoform 1

      See identical proteins and their annotated locations for NP_001093145.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AA423234, AK003822, AW047671
      Consensus CDS
      CCDS38751.1
      UniProtKB/Swiss-Prot
      B1AXP6, B1AXP7, B1AXP8, B1AXP9
      Related
      ENSMUSP00000103440.3, ENSMUST00000107810.3
      Conserved Domains (1) summary
      pfam10642
      Location:1 → 50
      Tom5; Mitochondrial import receptor subunit or translocase

    2. NM_001134646.1 → NP_001128118.1  mitochondrial import receptor subunit TOM5 homolog isoform 2

      See identical proteins and their annotated locations for NP_001128118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional frame-shifting exon in the central coding region, compared to variant 1, which results in a protein (isoform 2) with a longer and distinct C-terminus when compared to isoform 1.
      Source sequence(s)
      AA423234, AW047671, CA466100
      Consensus CDS
      CCDS51172.1
      UniProtKB/Swiss-Prot
      B1AXP6
      Related
      ENSMUSP00000103438.3, ENSMUST00000107808.3
      Conserved Domains (1) summary
      pfam15178
      Location:1 → 42
      TOM_sub5; Mitochondrial import receptor subunit TOM5 homolog

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      45105209..45108113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AXP6.1 GenPept UniProtKB/Swiss-Prot:B1AXP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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