Slc25a31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a31provided by MGI
Official Full Name: solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31provided by MGI
Primary source: MGI:MGI:1920583
See related: Ensembl:ENSMUSG00000069041 AllianceGenome:MGI:1920583
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ant4; Sfec; 1700034J06Rik
Summary: Predicted to enable ATP:ADP antiporter activity. Involved in male meiosis I; regulation of mitochondrial membrane permeability; and spermatogenesis. Located in mitochondrial inner membrane. Part of mitochondrial permeability transition pore complex. Is expressed in genitourinary system; lung; pituitary gland; and vertebral axis musculature. Orthologous to human SLC25A31 (solute carrier family 25 member 31). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 11.7) and placenta adult (RPKM 0.9) See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 19.5 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (40663301..40680525)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (40708871..40726094)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The essential role of adenine nucleotide translocase 4 on male reproductive function in mice.
Title: The essential role of adenine nucleotide translocase 4 on male reproductive function in mice.
Ant4 is a meiosis-specific gene expressed during both male and female gametogenesis however indispensable only during spermatogenesis and not oogenesis.
Title: Adenine nucleotide translocase 4 is expressed within embryonic ovaries and dispensable during oogenesis.
Studies indicate that Ant4 was expressed selectively in testis and sperm in adult mammals and was indeed essential for mouse spermatogenesis.
Title: Evolutionary genomics implies a specific function of Ant4 in mammalian and anole lizard male germ cells.
Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells.
Title: Adenine nucleotide translocase 4 deficiency leads to early meiotic arrest of murine male germ cells.
adenine nucleotide translocase 4 is essential for spermatogenesis
Title: Evolutionarily conserved mammalian adenine nucleotide translocase 4 is essential for spermatogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP:ADP antiporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial ADP transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial ATP transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
part_of mitochondrial permeability transition pore complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ADP/ATP translocase 4

Names: ADP,ATP carrier protein 4; ANT 4; adenine nucleotide translocase 4; adenine nucleotide translocator 4; solute carrier family 25 member 31; sperm flagellar energy carrier protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178386.3 → NP_848473.2 ADP/ATP translocase 4

See identical proteins and their annotated locations for NP_848473.2

Status: VALIDATED

Source sequence(s)

AK132722

Consensus CDS

CCDS17326.1

UniProtKB/Swiss-Prot

Q3V132, Q80W28

UniProtKB/TrEMBL

B2RTC8

Related

ENSMUSP00000088723.7, ENSMUST00000091184.9

Conserved Domains (2) summary

PTZ00169
Location:20 → 309

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:17 → 113

Mito_carr; Mitochondrial carrier protein