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    Cobll1 Cobl-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 319876, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cobll1provided by MGI
    Official Full Name
    Cobl-like 1provided by MGI
    Primary source
    MGI:MGI:2442894
    See related
    Ensembl:ENSMUSG00000034903 AllianceGenome:MGI:2442894
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Coblr1; 1810047P18Rik; D430044D16Rik
    Summary
    Predicted to enable actin monomer binding activity. Is expressed in several structures, including 1st branchial arch; extraembryonic component; forelimb bud; gut; and nose. Orthologous to human COBLL1 (cordon-bleu WH2 repeat protein like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in adrenal adult (RPKM 24.9), kidney adult (RPKM 14.3) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cobll1 in Genome Data Viewer
    Location:
    2 C1.3; 2 38.35 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (64918683..65069742, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (65088339..65239398, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13578 Neighboring gene growth factor receptor bound protein 14 Neighboring gene STARR-seq mESC enhancer starr_04666 Neighboring gene STARR-seq mESC enhancer starr_04667 Neighboring gene STARR-positive B cell enhancer mm9_chr2:64959532-64959832 Neighboring gene predicted gene, 57691 Neighboring gene STARR-seq mESC enhancer starr_04668 Neighboring gene STARR-positive B cell enhancer ABC_E4459 Neighboring gene STARR-seq mESC enhancer starr_04669 Neighboring gene STARR-seq mESC enhancer starr_04670 Neighboring gene predicted gene 13594 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 13593

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cordon-bleu is a conserved gene involved in neural tube formation. Carroll EA, et al. Dev Biol, 2003 Oct 1. PMID 14512015
    2. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    3. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin monomer binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cordon-bleu protein-like 1
    Names
    cobl-related 1
    cobl-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363076.1 → NP_001350005.1  cordon-bleu protein-like 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AL929129, AL929132, AL935171, BX321909
      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      pfam09469
      Location:188 → 266
      Cobl; Cordon-bleu ubiquitin-like domain
      cl26464
      Location:905 → 1176
      Atrophin-1; Atrophin-1 family

    2. NM_001363077.1 → NP_001350006.1  cordon-bleu protein-like 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL929129, AL929132, AL935171
      Consensus CDS
      CCDS89492.1
      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      UniProtKB/TrEMBL
      B1AZ14, D3Z6S2
      Related
      ENSMUSP00000108050.2, ENSMUST00000112431.8
      Conserved Domains (2) summary
      pfam09469
      Location:156 → 234
      Cobl; Cordon-bleu ubiquitin-like domain
      cl26464
      Location:873 → 1144
      Atrophin-1; Atrophin-1 family

    3. NM_027225.2 → NP_081501.1  cordon-bleu protein-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL929129, AL929132, AL935171
      Consensus CDS
      CCDS50595.1
      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Related
      ENSMUSP00000088412.4, ENSMUST00000090896.10
      Conserved Domains (2) summary
      pfam09469
      Location:156 → 234
      Cobl; Cordon-bleu ubiquitin-like domain
      cl00155
      Location:72 → 141
      UBQ; Ubiquitin-like proteins

    4. NM_177025.6 → NP_795999.2  cordon-bleu protein-like 1 isoform 1

      See identical proteins and their annotated locations for NP_795999.2

      Status: VALIDATED

      Source sequence(s)
      AL929129, AL929132, AL935171
      Consensus CDS
      CCDS16072.1
      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      UniProtKB/TrEMBL
      B1AZ15
      Related
      ENSMUSP00000099787.2, ENSMUST00000102726.8
      Conserved Domains (3) summary
      pfam09528
      Location:286 → 840
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      pfam09469
      Location:156 → 234
      Cobl; Cordon-bleu ubiquitin-like domain
      cl00155
      Location:72 → 141
      UBQ; Ubiquitin-like proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      64918683..65069742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499717.3 → XP_006499780.1  cordon-bleu protein-like 1 isoform X9

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:885 → 1156
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:155 → 231
      Cobl; Cordon-bleu ubiquitin-like domain

    2. XM_006499716.5 → XP_006499779.1  cordon-bleu protein-like 1 isoform X8

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:886 → 1157
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:156 → 232
      Cobl; Cordon-bleu ubiquitin-like domain

    3. XM_011239598.4 → XP_011237900.1  cordon-bleu protein-like 1 isoform X4

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:906 → 1177
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:176 → 252
      Cobl; Cordon-bleu ubiquitin-like domain

    4. XM_006499711.5 → XP_006499774.1  cordon-bleu protein-like 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:905 → 1176
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:175 → 251
      Cobl; Cordon-bleu ubiquitin-like domain

    5. XM_006499715.5 → XP_006499778.1  cordon-bleu protein-like 1 isoform X7

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:892 → 1163
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:176 → 254
      Cobl; Cordon-bleu ubiquitin-like domain

    6. XM_006499712.5 → XP_006499775.1  cordon-bleu protein-like 1 isoform X3

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:905 → 1176
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:176 → 252
      Cobl; Cordon-bleu ubiquitin-like domain

    7. XM_006499710.5 → XP_006499773.1  cordon-bleu protein-like 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:906 → 1177
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:176 → 252
      Cobl; Cordon-bleu ubiquitin-like domain

    8. XM_030251742.2 → XP_030107602.1  cordon-bleu protein-like 1 isoform X17

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:853 → 1124
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:175 → 253
      Cobl; Cordon-bleu ubiquitin-like domain

    9. XM_006499722.5 → XP_006499785.1  cordon-bleu protein-like 1 isoform X15

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:854 → 1125
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:175 → 253
      Cobl; Cordon-bleu ubiquitin-like domain

    10. XM_006499714.5 → XP_006499777.1  cordon-bleu protein-like 1 isoform X6

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:892 → 1163
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:175 → 253
      Cobl; Cordon-bleu ubiquitin-like domain

    11. XM_030251741.2 → XP_030107601.1  cordon-bleu protein-like 1 isoform X16

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:854 → 1125
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:176 → 254
      Cobl; Cordon-bleu ubiquitin-like domain

    12. XM_006499721.5 → XP_006499784.1  cordon-bleu protein-like 1 isoform X14

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:855 → 1126
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:176 → 254
      Cobl; Cordon-bleu ubiquitin-like domain

    13. XM_006499713.5 → XP_006499776.1  cordon-bleu protein-like 1 isoform X5

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:893 → 1164
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:176 → 254
      Cobl; Cordon-bleu ubiquitin-like domain

    14. XM_006499718.5 → XP_006499781.1  cordon-bleu protein-like 1 isoform X11

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:868 → 1139
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:176 → 252
      Cobl; Cordon-bleu ubiquitin-like domain

    15. XM_030251750.1 → XP_030107610.1  cordon-bleu protein-like 1 isoform X21

      Conserved Domains (1) summary
      PHA03247
      Location:646 → 917
      PHA03247; large tegument protein UL36; Provisional

    16. XM_030251749.1 → XP_030107609.1  cordon-bleu protein-like 1 isoform X21

      Conserved Domains (1) summary
      PHA03247
      Location:646 → 917
      PHA03247; large tegument protein UL36; Provisional

    17. XM_036162291.1 → XP_036018184.1  cordon-bleu protein-like 1 isoform X10

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (5) summary
      PHA03247
      Location:873 → 1144
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:156 → 234
      Cobl; Cordon-bleu ubiquitin-like domain
      cd21762
      Location:1211 → 1214
      WH2; actin-binding sequence [structural motif]
      cl28922
      Location:72 → 136
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
      cl41728
      Location:1190 → 1214
      WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

    18. XM_006499723.4 → XP_006499786.1  cordon-bleu protein-like 1 isoform X20

      See identical proteins and their annotated locations for XP_006499786.1

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:822 → 1093
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:92 → 168
      Cobl; Cordon-bleu ubiquitin-like domain

    19. XM_030251745.1 → XP_030107605.1  cordon-bleu protein-like 1 isoform X19

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:849 → 1120
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:132 → 210
      Cobl; Cordon-bleu ubiquitin-like domain

    20. XM_030251744.1 → XP_030107604.1  cordon-bleu protein-like 1 isoform X18

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:850 → 1121
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:133 → 211
      Cobl; Cordon-bleu ubiquitin-like domain

    21. XM_006499720.2 → XP_006499783.1  cordon-bleu protein-like 1 isoform X13

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:862 → 1133
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:132 → 208
      Cobl; Cordon-bleu ubiquitin-like domain

    22. XM_006499719.2 → XP_006499782.1  cordon-bleu protein-like 1 isoform X12

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:863 → 1134
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:133 → 209
      Cobl; Cordon-bleu ubiquitin-like domain

    23. XM_006499724.3 → XP_006499787.1  cordon-bleu protein-like 1 isoform X20

      See identical proteins and their annotated locations for XP_006499787.1

      UniProtKB/Swiss-Prot
      Q3UMF0, Q3UX63, Q69ZU2, Q6NXM0, Q7TQM8, Q8BWH3
      Conserved Domains (2) summary
      PHA03247
      Location:822 → 1093
      PHA03247; large tegument protein UL36; Provisional
      pfam09469
      Location:92 → 168
      Cobl; Cordon-bleu ubiquitin-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UMF0.2 GenPept UniProtKB/Swiss-Prot:Q3UMF0

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